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Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Spatial distribution of internet use and its determinants among reproductive age women in Jordan evidence 2023 DHS: a multilevel mixed effect analysis. [PDF]

open access: yesBMC Public Health
Kelkay JM   +8 more
europepmc   +1 more source
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Effect size analysis

2013 1st International Workshop on Data Analysis Patterns in Software Engineering (DAPSE), 2013
When we seek insight in collected data we are most often forced to limit our measurements to a portion of all individuals that can be hypothetically considered for observation. Nevertheless, as researchers, we want to draw more general conclusions that are valid beyond the restricted subset we are currently analyzing.
Emanuel Giger, Harald C. Gall
openaire   +1 more source

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