Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Estimating the effect size of moral contagion in online networks: A pre-registered replication and meta-analysis. [PDF]
PNAS NexusBrady WJ +3 more
europepmc +1 more source
The Effect of Particle Size Distribution on the Physical and Optical Properties of Cenosphere
, 2017 Won‐Jun Lee +5 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Letter to editor: Clarification regarding effect size reporting in "biportal endoscopic versus conventional open spine surgery: a systematic review and meta-analysis". [PDF]
Asian Spine JAbudayeh AH, Fishchenko IV.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Response to the letter to the editor: Clarification regarding effect size reporting in "biportal endoscopic versus conventional open spine surgery: a systematic review and meta-analysis". [PDF]
Asian Spine JYu A +8 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Winner's curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used. [PDF]
Front GenetSoave D, Hayalioglu M, Sun L.
europepmc +1 more source
Summary of effect sizes by intervention type.
Ali Asghar Norasteh (10092066) +6 more
openalex +1 more source