Results 231 to 240 of about 11,394,138 (261)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effects of an Ultrasound‑Guided Femoral, Sciatic, and Genitofemoral Nerve Block with Ropivacaine on EC₅ ₀ and EC₉ ₅ for High Saphenous Vein Ligation. [PDF]

Drug Des Devel Ther
Wang H, Chang J, Li Y, Chen L, Chen C, Wang Q, Gao X, Yang F, Chen S, Wang Y, Wu J, Wu G.   +11 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effective Interactions and Dynamical Properties of Thermoresponsive Hollow Microgels. [PDF]

Macromolecules
Rank L, Moreno AJ, Zaccarelli E.
europepmc   +1 more source

Is Stress a Foe or Friend? Mindset Matters for Effective Stress Coping and Distress Levels. [PDF]

Eur J Sport Sci
Yasuda Y, Lee H, Mizushima J, Matsuo G, Hirayama S, Mihashi M, Tsuchiya H.   +6 more
europepmc   +1 more source

Moxibustion combinations for diabetic peripheral neuropathy: a network meta-analysis of 40 randomised trials. [PDF]

Front Endocrinol (Lausanne)
Du D, Wang S, Chen X, Wang J, Zhang X, Gao Y.   +5 more
europepmc   +1 more source

What Works for Older Adults to Reduce Problematic Alcohol Use: A Delphi Study on Elements and Mechanisms in Interventions. [PDF]

Drug Alcohol Rev
van den Bulck FAE, Rozema AD, Bovens RHLM, van de Mheen D, Crutzen R.   +4 more
europepmc   +1 more source

Cost-efficient filtration and replication strategies match or exceed detection sensitivity for marine eDNA diversity at an intertidal site under a standardized laboratory workflow. [PDF]

PLoS One
Schulte NO, Craine JM, Devitt J, Miller GW, Gaines SD, Lafferty KD, Altstatt JM.   +6 more
europepmc   +1 more source

Modelling breeding strategies against genetic defects in a vulnerable cattle breed. [PDF]

PLoS One
Gustafsson E, Johansson AM, Johnsson M.
europepmc   +1 more source