Results 181 to 190 of about 1,616,662 (316)

Highly effective school principalship: An investigation of the views of six Solomon Islands' Community High School principals of what constitutes highly effective school principalship and their views on issues that impede their effective practice.

, 2008
Batu velakero iri kenaga, loboro mana vakatikili gira vano muzi (Highly effective leaders are at the front, walk in the middle, and encourage those from behind to catch up) My uncle Zorapa said, while I was on a 'pig-hunting' trip with him some twenty ...
Ruqebatu, Collin Bartholomew
core  

From classroom to community: leveraging teacher professional development research to build capacity in community-based organizations. [PDF]

Front Public Health
Kirk S, Weese M, Cruz J, Eisenkraft A, Mulhern M, Ramanadhan S.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessing Driven Steel Pile Capacity on Rock Using Empirical Approaches

, 2012
Methods of determining pile toe capacity for both small displacement driven steel piles and drilled sockets were collected. Working in conjunction with a local consulting firm, records of previous pile driving sites were collected. A process to determine
Morton, Timothy Scott
core  

Flexural behavior and crack development of reinforced geopolymer slabs with longitudinal voids: an experimental study. [PDF]

Sci Rep
Aziz YHA, Malky AE, El-Sayed TA.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Public health and cancer in Latin America: the region does not lack evidence; it lacks effective state capacity, enforceable laws, sustained prevention, and early diagnosis. [PDF]

Front Public Health
Duche-Pérez AB, Camargo-Riega AV, Paredes-Velazco R.   +2 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Challenges and Opportunities in Advancing Global Craniofacial Surgery: A Framework for Ethical, Sustainable, and Effective Collaboration. [PDF]

Plast Reconstr Surg Glob Open
Gomez DA, Palmer SK, Harshbarger R, Gosman AA, Arif F, Davis GL, Chong DK, Runyan CM, Nguyen PD.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source