Results 121 to 130 of about 6,029,728 (292)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Centre for Effective Services: strategy 2012 – 2014 and beyond [PDF]

, 2012
The Centre for Effective Services (CES) was established in 2008 in the Republic of Ireland, and in 2010 in Northern Ireland. The overall remit of the centre was to provide technical and organisational ‘expertise’ to promote and support the application of
Centre for Effective Services
core  

Parametric Analysis of Effective Tissue Thermal Conductivity, Thermal Wave Characteristic, and Pulsatile Blood Flow on Temperature Distribution during Thermal Therapy

, 2017
This study examines the coupled effects of pulsatile blood flow in a thermally significant blood vessel, the effective thermal conductivity of tumor tissue, and the thermal relaxation time in solid tissues on the temperature distributions during thermal ...
Shih, Tzu-Ching;Huang, Huang-Wen;Wei, Wei-Che;Horng, Tzyy-Leng
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

On the effective hydraulic conductivity and macrodispersivity for density-dependent groundwater flow

, 2013
In this paper, semi-analytical expressions of the effective hydraulic conductivity ( KE) and macrodispersivity ( αE) for 3D steady-state density-dependent groundwater flow are derived using a stationary spectral method.
Cox, Malcolm, Raiber, Matthias, Bian, Jianmin, Jiang, Zhenjiao   +3 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Effective Thermal Retardation in Aquifers of Heterogeneous Hydraulic Conductivity

Water Resources Research
Thermal retardation and dispersion are important processes affecting advective heat transport in sedimentary aquifers, yet little is known how they are influenced by heterogeneity of hydraulic conductivity.
Hannah Gebhardt, Alraune Zech, Gabriel C. Rau, Peter Bayer   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analysis of thermal-probe measurements using an iterative method to give sample conductivity and diffusivity data [PDF]

, 2004
The application of Microsoft Excel Solver routines to analyze data from a thermal probe placed in a number of samples is described. The successful application of the Solver routine to the thermal probe temperature time data requires the selection of an ...
Goodhew, SMR, Griffiths, R
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source