Results 161 to 170 of about 519,680 (305)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Clinical pain intensity is associated with greater cannabis demand among people who regularly use cannabis. [PDF]

Pain Rep
Bush NJ, Ferguson E, Funez-Ponce M, Yurasek A, Boissoneault J.   +4 more
europepmc   +1 more source

Types of Materials Used as Media in Biofilter Reactors and How Effective in Removing Biological and Chemical Oxygen Demand in Wastewater: A Systematic Review [PDF]

Muliyadi Muliyadi, Purwanto Purwanto, Sri Sumiyati, Sudarno Sudarno, Budiyono Budiyono, Budi Warsito, Nani Harihastuti   +6 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sustainable Cellulose Production from Agro-Industrial Waste: A Comprehensive Review. [PDF]

Polymers (Basel)
Darmenbayeva A, Rajasekharan R, Idrisheva Z, Aubakirova R, Dautova Z, Abylkassova G, Zhamanbayeva M, Afanasenkova I, Massalimova B.   +8 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Lightweight machine learning framework using temporal features for electric vehicle demand response forecasting on edge devices. [PDF]

Sci Rep
Durrani AM, Asar AU, Aziz A, Khan W, Yousaf MZ, Anjam F, Farooq U, Abdullah M, Shabaz M.   +8 more
europepmc   +1 more source

Scalable and cost-effective framework for continuous media-on-demand

, 2006
Dnc Nguyen
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The role of external factors in shaping the supply and demand of general practitioners in Iran: a qualitative study. [PDF]

BMC Prim Care
Amiresmaili M, Mehrolhassani MH, Iranmanesh M.   +2 more
europepmc   +1 more source