Results 111 to 120 of about 339,683 (291)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Revisiting the connection of baryon number, lepton number, and operator dimension
Physics Letters BThe effects of heavy new particles beyond the Standard Model can be conveniently captured through higher-dimensional effective operators. As noted long ago by Weinberg, the amount of baryon and lepton number an operator can carry is intricately connected
Julian Heeck, Diana Sokhashvili
doaj +1 more source
Identification and validation of effective teachers’ professional competence [PDF]
فصلنامه نوآوریهای آموزشی, 2014 The purpose of this research was to identify and validate the professional competences of effective teachers. For this purpose, a sample of 375 people among the teachers of Tehran elementary schools was selected using multistage sampling method.
Bijan Abdollahi +2 more
doaj
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The pseudo-effective cone of a compact Kähler manifold and varieties of negative Kodaira dimension [PDF]
, 2012 Sébastien Boucksom +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Effective dimension reduction for sparse functional data. [PDF]
Biometrika, 2015 Yao F, Lei E, Wu Y.
europepmc +1 more source
Effective field theory for one-dimensional valence-bond-solid phases and their symmetry protection [PDF]
, 2016 Yohei Fuji
openalex +1 more source