Results 71 to 80 of about 339,683 (291)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Anomalous dimension of a general effective gauge theory. Part I. Bosonic sector

open access: yesJournal of High Energy Physics
We classify the physical operators of the most general bosonic effective gauge theory up to dimension six using on-shell methods. Based on this classification, we compute the complete one-loop anomalous dimension employing both on-shell unitarity-based ...
Jason Aebischer   +2 more
doaj   +1 more source

2, 84, 30, 993, 560, 15456, 11962, 261485, . . .: higher dimension operators in the SM EFT

open access: yesJournal of High Energy Physics, 2017
In a companion paper [1], we show that operator bases for general effective field theories are controlled by the conformal algebra. Equations of motion and integration by parts identities can be systematically treated by organizing operators into ...
Brian Henning   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Generalized N-Dimensional Effective Temperature for Cryogenic Systems in Accelerator Physics

open access: yesQuantum Beam Science
Investigations into the properties of generalized effective temperature are conducted across arbitrary dimensions. Maxwell–Boltzmann distribution is displayed for one, two, and three dimensions, with effective temperatures expressed for each dimension ...
Heetae Kim, Chang-Soo Park
doaj   +1 more source

Constraints on dark matter annihilation to fermions and a photon

open access: yesJournal of High Energy Physics, 2018
We consider Majorana dark matter annihilation to fermion-anti-fermion pair and a photon in the effective field theory paradigm, by introducing dimension 6 and dimension 8 operators in the Lagrangian.
Debtosh Chowdhury   +2 more
doaj   +1 more source

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