Results 251 to 260 of about 12,005,894 (331)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Is lower training frequency more effective? Dose-response relationship of in-season flywheel resistance training on vertical jump and sprint performance in male team-sport athletes: a meta analysis. [PDF]

BMC Sports Sci Med Rehabil
Qu W, Lu D, Sun X, Sun J, He J, Song W, Li D.   +6 more
europepmc   +1 more source

Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients

, 2014
Blanca Xicoy, Josep‐María Ribera, Markus Müller, Olga García, Christian Hoffmann, Albert Oriol, Marcus Hentrich, Carlos Grande, Jan‐Christian Wasmuth, Jordi Esteve, Jan van Lunzen, Eloy del Potro, Heribert Knechten, Salut Brunet, Christoph Mayr, Lourdes Escoda, Philipp Schommers, Natalia Alonso, Ferran Vall‐Llovera, Montserrat Pérez, Mireia Morgades, José D. González, Angeles Fernández, Jan Thoden, Nicola Gökbuget, Dieter Hoelzer, Gerd Fätkenheuer, Christoph Wyen, for the PETHEMA Group and German HIV Lymphoma Cohort   +28 more
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Size-Specific Dose Estimate and Effective Dose for Pediatric Computed Tomography. [PDF]

J Med Phys
Khan R, Shah MA, Wahab S, Khan RA.
europepmc   +1 more source

Minimum effective dose of oral vitamin B12 to treat elderly people with mild vitamin b12 deficiency

, 2003
Simone J. P. M. Eussen, C.P.G.M. de Groot, Robert Clarke, J. Scneede, W.A. van Staveren   +4 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Effective dose to immune cells combined with platelet-to-lymphocyte ratio predicts lymphopenia and prognosis in unresectable locally advanced non-small cell lung cancer. [PDF]

Front Immunol
Yang H, Ma J, Tian C, Bao S, Zhang J, Wang F, Xu Y, Yu J, Chen D.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation. [PDF]

Sci Rep
Liao M, Wu XR, Hu JN, Lin XZ, Zhao TY, Sun H.   +5 more
europepmc   +1 more source