Results 31 to 40 of about 484,566 (288)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Calculation of complex DNA damage induced by ions

, 2011
This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be ...
Gallagher, David C., Solov'yov, Andrey V., Surdutovich, Eugene   +2 more
core   +1 more source

Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating [PDF]

, 2016
AIMS: To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA). METHODS AND RESULTS: Forty-one consecutive patients with suspected (n = 35) or known coronary artery ...
Husmann, L., Valenta, I., Gaemperli, O., Adda, O., Treyer, V., Wyss, C., Veit-Haibach, P., Tatsugami, F., von Schulthess, G K., Kaufmann, P A.   +9 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

CT Coronary Angiography with 100kV tube voltage and a low noise reconstruction filter in non-obese patients: evaluation of radiation dose and diagnostic quality of 2D and 3D image reconstructions using open source software (OsiriX) [PDF]

, 2012
INTRODUCTION AND PURPOSE. Computed tomography coronary angiography (CTCA) has seen a dramatic evolution in the last decade owing to the availability of multislice CT scanners with 64 detector rows and beyond.
FAGGIONI, LORENZO
core  

Limitations in Predicting the Space Radiation Health Risk for Exploration Astronauts [PDF]

, 2018
Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews ...
Auñón-Chancellor, Serena M., Blue, Rebecca S., Cengel, Keith A., Chancellor, Jeffery C., Katzgraber, Helmut G., Kennedy, Ann R., Rubins, Kathleen H.   +6 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Low-dose Radiation Effects and Intracellular Signaling Pathways

YAKUGAKU ZASSHI, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Keiji, Suzuki, Seiji, Kodama, Masami, Watanabe   +2 more
openaire   +3 more sources

Influence of Image Acquisition on Radiation Dose and Image Quality: Full versus Narrow Phase Window Acquisition Using 320 MDCT [PDF]

, 2013
Purpose. To compare radiation dose and image quality using predefined narrow phase window versus complete phase window with dose modulation during R-R using 320-row MDCTA. Methods:. 114 patients underwent coronary CTA study using 320-row MDCT scanner. 87
Blankstein, Ron, Budoff, Matthew, Clouse, Melvin E., Khan, Atif, Khosa, Faisal, Nasir, Khurram, Shuaib, Waqas   +6 more
core   +4 more sources