Results 61 to 70 of about 707,975 (264)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Confinement effects in premelting dynamics [PDF]
Physical Review E, 2017 We examine the effects of confinement on the dynamics of premelted films driven by thermomolecular pressure gradients. Our approach is to modify a well-studied setting in which the thermomolecular pressure gradient is driven by a temperature gradient parallel to an interfacially premelted elastic wall.
Pramanik, Satyajit, Wettlaufer, John S.
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Electronic Notes in Theoretical Computer Science, 2008 AbstractWe investigate computable subshifts and the connection with effective symbolic dynamics. It is shown that a decidable Π10 class P is a subshift if and only if there is a computable function F mapping 2N to 2N such that P is the set of itineraries of elements of 2N. A Π10 subshift is constructed which has no computable element.
Department of Mathematics, University of Florida, Gainesville, FL 32611-8105, USA ( host institution ) +3 more
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A mean free path approach to the micro/nanochannel gas flows
Advances in Aerodynamics, 2020 We investigate the gas flows near to solid surfaces in terms of the local spatial variation in the molecular mean free path (MFP). Molecular dynamics (MD) is the appropriate scientific tool for obtaining molecularly-accurate dynamic information in micro ...
Jianfei Xie
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Out of time ordered effective dynamics of a quartic oscillator
SciPost Physics, 2019 We study the dynamics of a quantum Brownian particle weakly coupled to a thermal bath. Working in the Schwinger-Keldysh formalism, we develop an effective action of the particle up to quartic terms. We demonstrate that this quartic effective theory is
Bidisha Chakrabarty, Soumyadeep Chaudhuri
doaj +1 more source