Results 71 to 80 of about 707,975 (264)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

THE STRUCTURE AND DYNAMICS OF A RHETORICALLY EFFECTIVE PRESENTATION [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2019
Since public speaking is ultimately an act of persuasion, the paper attempts to determine the way in which the ancient principles of rhetoric are still valid in contemporary professional communication, underlying the structure and dynamics of an ...
GABRIELA DUMBRAVĂ
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Effective One-Dimensional Reduction of Multicompartment Complex Systems Dynamics

open access: yesPhysical Review X
A broad class of systems, including ecological, epidemiological, and sociological ones, are characterized by populations of individuals assigned to specific categories, e.g., a chemical species, an opinion, or an epidemic state, that are modeled as ...
Giorgio Vittorio Visco   +4 more
doaj   +1 more source

Research on the performance and application of nano-MgO modified ultrafine cement-based sealing materials

open access: yesCase Studies in Construction Materials
The gas tightness and strength of cement-based sealing materials are critical factors influencing coalbed methane (CBM) extraction efficiency. However, ordinary cement-based sealing materials tend to lose water, shrink, and develop cracks, which results ...
Jiajia Zhao   +6 more
doaj   +1 more source

Effective relational dynamics

open access: yesJournal of Physics: Conference Series, 2012
We provide a synopsis of an effective approach to the problem of time in the semiclassical regime. The essential features of this new approach to evaluating relational quantum dynamics in constrained systems are illustrated by means of a simple toy model.
openaire   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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