Results 131 to 140 of about 4,864,213 (340)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Many-body perturbation theory for strongly correlated effective Hamiltonians using effective field theory methods

SciPost Physics
Introducing low-energy effective Hamiltonians is usual to grasp most correlations in quantum many-body problems. For instance, such effective Hamiltonians can be treated at the mean-field level to reproduce some physical properties of interest. Employing
Raphaël Photopoulos, Antoine Boulet
doaj   +1 more source

Cosmic Microwave Background from Effective Field Theory

Universe, 2019
In this work, we study the key role of generic Effective Field Theory (EFT) framework to quantify the correlation functions in a quasi de Sitter background for an arbitrary initial choice of the quantum vacuum state. We perform the computation in unitary
Sayantan Choudhury
doaj   +1 more source

Unitarity problems for an effective field theory description of early universe cosmology. [PDF]

Eur Phys J C Part Fields, 2022
Brandenberger R, Kamali V.
europepmc   +1 more source

Effective Field Theory of non-Attractor Inflation

, 2015
We present the model-independent studies of non attractor inflation in the context of effective field theory (EFT) of inflation. Within the EFT approach two independent branches of non-attractor inflation solutions are discovered in which a near scale ...
Akhshik, Mohammad, Firouzjahi, Hassan, Jazayeri, Sadra   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effective potential in Lorentz-breaking field theory models

European Physical Journal C: Particles and Fields, 2017
We calculate explicitly the one-loop effective potential in different Lorentz-breaking field theory models. First, we consider a Yukawa-like theory and some examples of Lorentz-violating extensions of scalar QED.
A. P. Baeta Scarpelli, L. C. T. Brito, J. C. C. Felipe, J. R. Nascimento, A. Yu. Petrov   +4 more
doaj   +1 more source

The [Formula: see text] channel of proton-proton scattering in new chiral effective field theory power counting. [PDF]

Sci Rep, 2023
Behzadmoghaddam B, Radin M, Bayegan S.
europepmc   +1 more source

On String Field Theory and Effective Actions

, 1992
A truncation of string field theory is compared with the duality invariant effective action of $D=4, N=4$ heterotic strings to cubic order. The three string vertex must satisfy a set of compatibility conditions.
Ademollo, Amit Giveon, Bergshoeff, Bienkowska, Bonini, Caneschi, Cohn, Covri, D'Adda, de Roo, de Roo, de Roo, Dine, Eskin, Giveon, Giveon, Giveon, Giveon, Green, Gross, Klebanov, Kugo, Kugo, Kugo, LeClair, LeClair, Li, Mathur, Mukherji, Narain, Narain, Ohta, Ooguri, Saadi, Sciuto, Sen, Sen, Sen, Sonoda, Sonoda, Wagemans, Witten, Witten, Witten, Zwiebach, Zwiebach   +45 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source