Results 141 to 150 of about 4,697,126 (351)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Effective potential in Lorentz-breaking field theory models

open access: yesEuropean Physical Journal C: Particles and Fields, 2017
We calculate explicitly the one-loop effective potential in different Lorentz-breaking field theory models. First, we consider a Yukawa-like theory and some examples of Lorentz-violating extensions of scalar QED.
A. P. Baeta Scarpelli   +4 more
doaj   +1 more source

Convergence of chiral effective field theory

open access: yes, 2002
We formulate the expansion for the mass of the nucleon as a function of pion mass within chiral perturbation theory using a number of different ultra-violet regularisation schemes; including dimensional regularisation and various finite-ranged regulators.
A.W. Thomas   +36 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Effective field theory of black hole echoes

open access: yesJournal of High Energy Physics, 2018
Gravitational wave ‘echoes’ during black-hole merging events have been advocated as possible signals of modifications to gravity in the strong-field (but semiclassical) regime.
C. P. Burgess   +2 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Renormalizability of Effective Scalar Field Theory

open access: yes, 1993
We present a comprehensive discussion of the consistency of the effective quantum field theory of a single $Z_2$ symmetric scalar field. The theory is constructed from a bare Euclidean action which at a scale much greater than the particle's mass is ...
Oxford Ox Np   +2 more
core   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Cosmic Microwave Background from Effective Field Theory

open access: yesUniverse, 2019
In this work, we study the key role of generic Effective Field Theory (EFT) framework to quantify the correlation functions in a quasi de Sitter background for an arbitrary initial choice of the quantum vacuum state. We perform the computation in unitary
Sayantan Choudhury
doaj   +1 more source

Home - About - Disclaimer - Privacy