Results 71 to 80 of about 49,957 (261)

In Pursuit of Financial Justice: Local African Communities’ Quest for Legal Redress Against Business-Related Human Rights Abuses

open access: yesModern Africa, 2019
Mining corporations in Africa stand accused of violating human rights. This article gives a voice to the plight suffered by local African communities in accessing justice to remedy the violation of their human rights as a result of the business ...
Laila Abdul Latif
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Homeopathic and conventional treatment of hypertensive urgency

open access: yesActa Médica del Centro, 2020
Introduction: arterial hypertension is a health problem with high prevalence worldwide, considered one of the main cardiovascular risk factors, being a very frequent reason for consultation, both in primary care and in emergency services.
Belkys Ocampo Soto   +5 more
doaj  

INSTITUTIONAL INEQUALITY AND THE DYNAMICS OF COURAGE

open access: yesThe Windsor Yearbook of Access to Justice, 2013
One of the greatest challenges of anti-discrimination law is institutionalized inequality.  Recognized in law as systemic discrimination, it is embedded in processes, practices, norms, and relationships that reproduce and accentuate inequality.
Colleen Sheppard
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Righting Wrongs at Home: The Potential of Domestic Judicial Remedies in Determining and Allocating Responsibility for Human Rights Violations in European Integrated Border Management

open access: yesEuropean Constitutional Law Review
Shared administration – EU migration agencies – The European Border and Coast Guard Agency Frontex – European Integrated Border Management and responsibility gaps – Unclear division of obligations in Frontex’s mandate – EU composite legal order and ...
Elmin Omičević   +1 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

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