Results 141 to 150 of about 225,712 (334)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

The role of atrial natriuretic peptide (ANP) in chronic liver disease. [PDF]

, 1993
Almeida, Angeli, Arendt, Arendt, Badalamenti, Ballermann, Bendtsen, Bernardi, Bernardi, Beutler, Brenard, Buckalew, Cachofeiro, Cantin, Chinkers, Colantonio, De Wardener, Dussaule, Epstein, Epstein, Field, Firth, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Gerbes, Ginés, Ginés, Gutkowska, Heim, Henriksen, Henriksen, Henriksen, Henriksen, Inagami, Jiménez, Klepetko, Kollenda, Kollenda, Kramer, La Villa, Laffi, Lang, Lang, Larose, Lenz, López, Maack, Maher, Miyase, Morali, Moreau, Morgan, Naccarato, Nair, Needleman, Panos, Panos, Panos, Pilz, Rashed, Rector, Salerno, Salerno, Schrier, Tesar, Tesar, Trevisani, Tulassay, Uemura, Vinel, Vollmar, Warner, Wilcox, Withrington, Witthaut   +82 more
core   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

THE EFFECTS OF INTRAVENOUSLY INFUSED VASODILATORS ON THE RENAL PLASMA FLOW AND RENAL TUBULES

The Kurume Medical Journal, 1976
Nitroglycerin increased the renal plasma flow and altered electrolyte excretion. Perhexiline, i. v., caused an increase in sodium, chloride and osmolar clearance without the changes in the renal plasma flow. An elevation of the tubular sodium rejection fraction probably contributed to the increased solute clearance.
openaire   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Cold Atmospheric Plasma‐Activated In Situ Hydrogel Induces Hair Regeneration Via Immune Microenvironment Remodeling

Advanced Science, EarlyView.
A cold atmospheric plasma‐activated in situ hydrogel (CAPgel/IL2) delivers reactive oxygen species and interleukin‐2 to modulate the hair follicle immune microenvironment, enhancing regulatory T‐cell expansion, dermal papilla cell proliferation, and the telogen‐to‐anagen transition for robust hair regeneration.
Jung Suk Kim, Junho Byun, Jaehyun Choi, Dongun Jin, Qiaoyun Li, Jaiwoo Lee, Han‐Gon Choi, Yu‐Kyoung Oh   +7 more
wiley   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Measurement of the Glomerular Filtration Rate and the Effective Renal Plasma Flow Using Sodium Thiosulphate and p-Amino-Hippuric Acid

Journal of Clinical Pathology, 1949
A. Dick, C. Davies
semanticscholar   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source