Results 61 to 70 of about 1,505,358 (290)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Effective Tolman temperature induced by trace anomaly
European Physical Journal C: Particles and Fields, 2017 Despite the finiteness of stress tensor for a scalar field on the four-dimensional Schwarzschild black hole in the Israel–Hartle–Hawking vacuum, the Tolman temperature in thermal equilibrium is certainly divergent on the horizon due to the infinite blue ...
Myungseok Eune, Yongwan Gim, Wontae Kim
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Effective temperature of self-similar time series
Condensed Matter Physics, 2005 Within slightly non-extensive statistics and the related numerical model, a picture is elaborated to treat self-similar time series as a thermodynamic system.
A.Olemskoi, S.Kokhan
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Journal of Integrative Agriculture, 2018 The armyworm Mythimna roseilinea (Walker) is a major pest of grain crops in South China. So far little is known about its basic biology and ecology, making prediction of population dynamics difficult.
Jian-yang QIN +5 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
A Mesoscale Particle Method for Simulation of Boundary Slip Phenomena in Fluid Systems
ComputationThe present work aimed to develop a simple simulation tool to support studies of slip and other non-traditional boundary conditions in solid–fluid interactions.
Alexander E. Filippov +2 more
doaj +1 more source
Homemade Nucleic Acid Preservation Buffer Proves Effective in Preserving the Equine Faecal Microbiota over Time at Ambient Temperatures [PDF]
, 2023 Ashley B. Ward +9 more
openalex +1 more source