Results 131 to 140 of about 5,134,083 (307)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Translating evidence into primary care: Singapore’s 2025 national osteoporosis guideline and a multilevel framework for assessing guideline impact in mixed health systems

Family Medicine and Community Health
Objective Osteoporosis is a major contributor to morbidity and mortality worldwide, yet underdiagnosis and undertreatment remain pervasive across diverse health systems, including Singapore’s mixed public–private primary care landscape.
Kin Ming Chan, Cheryl Wei Yan Tan, Eu Leong Yong, Phyllis Kim, M Premikha, Valentina Ricci, Shu Jun Kan, Bernard Thong, Derek Shangxian Choong, Alexis Guat Cheng Ang, Andre Teck Huat Tan, Chee Kian Chew, Li Wei Cho, Thomas FJ King, Yang Chua, Joyce Suang Bee Koh, Victor Seah, Christine Ng, Kok Wai Kee, Kenneth Wei Qiang Choo, Shi Mun Chan, Murshitha Shereen Bte Sayed Majunoon, Jonathan Cheng Hsun Yeo, Anna Purani Raman Singarasoo, Cheuk Ying Chan   +24 more
doaj   +1 more source

Addendum clinical guideline screening and prioritisation criteria

, 2012
Clinical guideline prioritisation criteria are commonly utilised by various key international bodies and organisations in order to select clinical guidelines for development, appraisal or endorsement at national, regional and local level.
National Clinical Effectiveness Committee
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Abscopal Effects, Clastogenic Effects and Bystander Effects: 70 Years of Non-Targeted Effects of Radiation

Radiation Research
In vitro and in vivo observations accumulated over several decades have firmly shown that the biological effects of ionizing radiation can spread from irradiated cells/tissues to non-targeted cells/tissues. Redox-modulated intercellular communication mechanisms that include a role for secreted factors and gap junctions, can mediate these non-targeted ...
Lyng, Fiona M., Azzam, Edouard I.
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

How are effectiveness reviews carried out?

, 2016
Since 2011, Oxfam Great Britain (GB) has been conducting rigorous evaluations annually on samples of randomly selected mature projects (projects which are a substantial way through implementation or have finished).

core   +1 more source

Part 3, Section 2: Core Requirements,Section 2.5: Institution Effectiveness [PDF]

, 2011
Compliance report statement of institutional effectiveness.The institution engages in ongoing, integrated, and institution-wide research-based planning and evaluation processes that (1) incorporate a systematic review of institutional mission, goals, and

core   +1 more source

The Effect of Leadership Effectiveness on the Work Effectiveness of the Staffs

Journal of International Conference Proceedings, 2018
This research analyzed the effect of leadership effectiveness on employee effectiveness. The object of this research is Universitas Negeri Manado (UNIMA) as the Higher Education Institution. Research problem refers to data phenomenon in UNIMA. The fact presents that the staffs do not have maximum presence since they only go to work for 18 days per ...
openaire   +1 more source