Results 111 to 120 of about 4,197,911 (316)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Barriers and facilitators to the implementation of antenatal syphilis screening and treatment for the prevention of congenital syphilis in the Democratic Republic of Congo and Zambia: results of qualitative formative research

BMC Health Services Research, 2017
Background The impact of untreated syphilis during pregnancy on neonatal health remains a major public health threat worldwide. Given the high prevalence of syphilis during pregnancy in Zambia and Democratic Republic of Congo (DRC), the Preventive ...
Dalau Nkamba, Musaku Mwenechanya, Arlette Mavila Kilonga, Maria Luisa Cafferata, Amanda Mabel Berrueta, Agustina Mazzoni, Fernando Althabe, Ezequiel Garcia-Elorrio, Antoniette K. Tshefu, Elwyn Chomba, Pierre M. Buekens, Maria Belizan   +11 more
doaj   +1 more source

The necessary alignment between technology innovation effectiveness and operational effectiveness

, 2009
Organisations are increasingly investing in complex technological innovations such as enterprise information systems with the aim of improving the operations of the business, and in this way gaining competitive advantage.
Ricardo Santa, Paul Hyland, Bretherton, Phil, Mario Ferrer, Ferrer, Mario, Santa, Ricardo, Phil Bretherton, Hyland, Paul   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Part 3, Section 3.3.1: Institutional Effectiveness

, 2011
Compliance report statement of institutional effectiveness.The institution identifies expected outcomes, assesses the extent to which it achieves these outcomes, and provides evidence of improvement based on analysis of the results in each of the ...

core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A global living systematic review and meta-analysis hub of emerging vaccines in pregnancy and childhood

Reproductive Health
The COVID-19 pandemic accelerated vaccine development and generated a rapidly evolving body of evidence before and after the vaccine rollout. We developed a robust online platform to efficiently synthesize this emerging information for current and future
Agustín Ciapponi, Ariel Bardach, Mabel Berrueta, Jamile Ballivian, Martin Brizuela, Julieta Caravario, Noelia Castellana, Daniel Comande, Esteban Couto, Agustina Mazzoni, Vanesa Ortega, Edward P. K. Parker, Juan M. Sambade, Salva Florencia, Juan Pablo Smutny, Katharina Stegelmann, Xu Xiong, Andy Stergachis, Flor M. Munoz, Pierre Buekens   +19 more
doaj   +1 more source

Effectiveness Review: Improving Women's Leadership and Effectiveness in Agricultural Governance, Nigeria

, 2012
The 'Improving Women's Leadership and Effectiveness in Agricultural Governance' project in Nigeria aims to increase women's leadership and participation in agricultural decision-making and governance.
Bishop, David
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source