Results 81 to 90 of about 4,197,911 (316)

The efficacy-effectiveness distinction in trials of alcohol brief intervention. [PDF]

, 2014
Three recent sets of null findings from trials of alcohol brief intervention (BI) have been disappointing to those who wish to see a reduction in alcohol-related harm through the widespread dissemination of BI.
Nick Heather, Heather, Nick
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Effectiveness of catch-up and at-birth nirsevimab immunisation against RSV hospital admission in the first year of life: a population-based case–control study, Spain, 2023/24 season

Eurosurveillance
Background Respiratory syncytial virus (RSV) causes substantial morbidity in infants 
the Nirsevimab Effectiveness Study Collaborators
doaj   +1 more source

Cost-effectiveness analysis of atezolizumab in advanced triple-negative breast cancer

BMC Health Services Research, 2020
Background The IMpassion130 trial demonstrated that adding atezolizumab to nanoparticle albumin-bound (nab)-paclitaxel improved the survival of patients with untreated, advanced, programmed death ligand 1 (PDL1)-positive triple-negative breast cancer ...
Lee Cheng Phua, Soo Chin Lee, Kwong Ng, Mohamed Ismail Abdul Aziz   +3 more
doaj   +1 more source

Assessing the ability of an instrumental variable causal forest algorithm to personalize treatment evidence using observational data: the case of early surgery for shoulder fracture

BMC Medical Research Methodology, 2022
Background Comparative effectiveness research (CER) using observational databases has been suggested to obtain personalized evidence of treatment effectiveness.
John M. Brooks, Cole G. Chapman, Sarah B. Floyd, Brian K. Chen, Charles A. Thigpen, Michael Kissenberth   +5 more
doaj   +1 more source

Developing, testing and using theoretical models of educational effectiveness for promoting quality in education [PDF]

, 2015
This paper argues that the dynamic model of educational effectiveness can be used to establish stronger links between educational effectiveness research (EER) and school improvement.
Creemers, Bert, Kyriakides, Leonidas
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Effect of Health Promoting Hospitals\' Standards on Hospital Performance A Case Study in Fatemieh Hospital in Shahrod

بیمارستان, 2015
Background: Hospitals are best places to provide preventive and health promotion services along with healthcare services. These studies aimed at determine the effect of establishing health promoting hospitals’ standards on hospitals indicators in ...
shima naderi, mohammad amiri, leila Riahi   +2 more
doaj  

Factors affecting Mathematics achievement of first-year secondary school students in Central Uganda

South African Journal of Education, 2015
This study explores the sources of variability in Mathematics achievement of Ugandan students at the student, classroom and school level. The Mathematics score and questionnaire responses of 4,819 first-year secondary school students (Grade Seven, about ...
Henry Nsubuga Kiwanuka, Jan Van Damme, Wim Van Den Noortgate, Dickson Nkafu Anumendem, Speranza Namusisi   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source