Results 141 to 150 of about 5,400,433 (309)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Content validity of the modified EQ-HWB-9 in a sample of Argentinean patients, informal caregivers, and members of the general public

Health and Quality of Life Outcomes
Background In response to the challenge of measuring the impact of health, social care, and informal caregiving on quality of life, the EuroQol Group developed the Experimental EuroQol Health and Wellbeing (EQ-HWB-9).
Maria Belizan, Natalí Ini, Fernando Argento, Michael Herdman, Clara Mukuria, Federico Augustovski   +5 more
doaj   +1 more source

The Effect of Leadership Effectiveness on the Work Effectiveness of the Staffs

Journal of International Conference Proceedings, 2018
This research analyzed the effect of leadership effectiveness on employee effectiveness. The object of this research is Universitas Negeri Manado (UNIMA) as the Higher Education Institution. Research problem refers to data phenomenon in UNIMA. The fact presents that the staffs do not have maximum presence since they only go to work for 18 days per ...
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Minutes, Institutional Effectiveness Committee Meeting, July 21, 2008

, 2008
Minutes from the July 21, 2008, meeting of the Institutional Effectiveness ...
Institutional Effectiveness Committee, University of South Florida St. Petersburg. Planning, Effectiveness, and Budgeting Committee, University of South Florida St. Petersburg. Institutional Effectiveness Committee   +2 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

How are effectiveness reviews carried out?

, 2016
Since 2011, Oxfam Great Britain (GB) has been conducting rigorous evaluations annually on samples of randomly selected mature projects (projects which are a substantial way through implementation or have finished).

core  

Effect of target detection on the testing effect

Acta Psychologica
A change in the recognition decision criterion occurs when target-detection tasks are conducted concurrently with memory retrieval tasks, in which words presented alongside the target are perceived more frequently as previously learned. This raises the question: Does target detection during memory retrieval enhance the processing of concurrently ...
Yueqing Dong, Siqi Zheng, Xuan Liu, Chunyan Hao, Danyu Fu   +4 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Conceptualising differentiated integration: governance, effectiveness and legitimacy

, 2019
In light of rising internal cleavages and centrifugal tendencies, differentiated integration (DI) has (re)arisen as a major topic in debates on the future of the European Union.
Lavenex, Sandra, Krizic, Ivo
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