Results 181 to 190 of about 5,148,843 (306)

Did You Know That Confounding Could Bias Results Obtained within an Economic Evaluation? [PDF]

Med Decis Making
LaRue S, Paulden M, Talbot D, Guertin JR.   +3 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Cost-Effectiveness of Reducing HIV Infections Through Screening and Treating Alcohol Use and Depression in KwaZulu-Natal, South Africa: A Mathematical Modeling Study. [PDF]

J Acquir Immune Defic Syndr
Jeetoo M, Yeo YR, Charles DL, Moll AP, Shenoi SV, Morojele NK, Mbaya JK, Zama P, Gasa S, Francis JM, Braithwaite RS.   +10 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Pathways to integrated learning outcomes in professional and entrepreneurship education: Evidence from student perceptions. [PDF]

PLoS One
Zhang J, Usman K, Yang H, Yan Q.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Rapid evidence profile #63: Reviewing the effectiveness of cannabis on symptoms of select conditions

An overview of the best available research evidence from around the world (i.e., evidence syntheses) and local research evidence (i.e., single studies) and may include a scan of experiences from other countries and from Canadian provinces and territories,
Jaspal, A, Phelps, A, Waddell, K, Wilson, MG   +3 more
core  

Navigating the Human Side of AI: A Socio-Technical Model of Employee Attitudes Toward Algorithmic Recruitment. [PDF]

Behav Sci (Basel)
Beyari H.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

An empirical analysis of the hedging effectiveness of currency futures [PDF]

Existing research on the hedging effectiveness of currency futures assumes that futures positions are continuously adjusted. This is an unrealistic assumption in practice.
Roon, F.A. de, Jong, A. de, Veld, C.H.
core