Results 131 to 140 of about 5,400,433 (309)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Part 3, Section 2: Core Requirements,Section 2.5: Institution Effectiveness

, 2011
Compliance report statement of institutional effectiveness.The institution engages in ongoing, integrated, and institution-wide research-based planning and evaluation processes that (1) incorporate a systematic review of institutional mission, goals, and

core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Team Effectiveness and Leadership Roles [PDF]

In this study we aim to explain the patterns of leadership roles for team effectiveness in non economic organizations compared to economic organizations.
Duygulu, Ethem, Ciraklar, Nurcan
core  

Appendix_STM_TransitionProb_online_supp – Supplemental material for Alternative Conversion Methods for Transition Probabilities in State-Transition Models: Validity and Impact on Comparative Effectiveness and Cost-Effectiveness

, 2019
Supplemental material, Appendix_STM_TransitionProb_online_supp for Alternative Conversion Methods for Transition Probabilities in State-Transition Models: Validity and Impact on Comparative Effectiveness and Cost-Effectiveness by Beate Jahn, Christina ...
Uwe Siebert (495818), Marvin Bundo (4516399), Niki Popper (3564440), Ursula Rochau (2553013), Christina Kurzthaler (4516393), Elamin H. Elbasha (6897185), Jagpreet Chhatwal (299895), Annette Conrads-Frank (6897188), Gaby Sroczynski (4516390), Christoph Urach (3564446), Beate Jahn (170765)   +10 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Translating evidence into primary care: Singapore’s 2025 national osteoporosis guideline and a multilevel framework for assessing guideline impact in mixed health systems

Family Medicine and Community Health
Objective Osteoporosis is a major contributor to morbidity and mortality worldwide, yet underdiagnosis and undertreatment remain pervasive across diverse health systems, including Singapore’s mixed public–private primary care landscape.
Kin Ming Chan, Cheryl Wei Yan Tan, Eu Leong Yong, Phyllis Kim, M Premikha, Valentina Ricci, Shu Jun Kan, Bernard Thong, Derek Shangxian Choong, Alexis Guat Cheng Ang, Andre Teck Huat Tan, Chee Kian Chew, Li Wei Cho, Thomas FJ King, Yang Chua, Joyce Suang Bee Koh, Victor Seah, Christine Ng, Kok Wai Kee, Kenneth Wei Qiang Choo, Shi Mun Chan, Murshitha Shereen Bte Sayed Majunoon, Jonathan Cheng Hsun Yeo, Anna Purani Raman Singarasoo, Cheuk Ying Chan   +24 more
doaj   +1 more source

Abscopal Effects, Clastogenic Effects and Bystander Effects: 70 Years of Non-Targeted Effects of Radiation

Radiation Research
In vitro and in vivo observations accumulated over several decades have firmly shown that the biological effects of ionizing radiation can spread from irradiated cells/tissues to non-targeted cells/tissues. Redox-modulated intercellular communication mechanisms that include a role for secreted factors and gap junctions, can mediate these non-targeted ...
Lyng, Fiona M., Azzam, Edouard I.
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source