Results 121 to 130 of about 8,036,556 (293)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effectiveness of 2D fingerprints for scaffold hopping

, 2011
Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J., Holliday, J.D., O'Dowd, C., Willett, P.   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Better Way to Generate and Use Comparative-Effectiveness Research [PDF]

, 2009
President Barack Obama, former U.S. Senate majority leader Tom Daschle, and others propose a new government agency that would evaluate the relative effectiveness of medical treatments. The need for "comparative-effectiveness research" is great.
Michael F. Cannon
core  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The interplay between students’ home literacy environment, reading attitudes and comprehension: a serial mediation analysis using PIRLS 2021-data

Large-scale Assessments in Education
Background Providing a rich home literacy environment (HLE) is considered to contribute to the development of students’ reading comprehension. However, less research attention has been given to the underlying mechanisms that influence this relationship ...
Renée Claes, Jana Laga, Katrijn Denies, Nele Bleukx, Jonas Dockx, Hilde Van Keer, Koen Aesaert   +6 more
doaj   +1 more source

Pengaruh Kecepatan Fluida Terhadap Nilai Efektivitas pada Heat Exchanger Tipe Shell and Tube (The Effect of Fluid Flow Velocity to Determine the Effectiveness of Heat Exchanger Shell and Tube) [PDF]

, 2016
As a device to exchange heat from hot fluid to colder fluid, a heat exchanger is supposed to have high effectiveness. Theoretically, the increase of fluid rate would increase the effectiveness.
PUSPITA DEWI, MEIKE
core  

Effectiveness of Hindman's theorem for bounded sums

, 2016
We consider the strength and effective content of restricted versions of Hindman's Theorem in which the number of colors is specified and the length of the sums has a specified finite bound. Let $\mathsf{HT}^{\leq n}_k$ denote the assertion that for each
A Rumyantsev, C Jockusch, CT Chong, H Towsner, JE Baumgartner, N Hindman, N Hindman, PA Cholak, RI Soare, S Simpson, WW Comfort   +10 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source