Results 91 to 100 of about 297,502 (291)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells [PDF]

, 2012
Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta.
Cakir, Cahid, Tolga O Bozkurt, Sebastian Schornack, Cahid Cakir, Mireille van Damme, Cahid Cakir (142118), Bozkurt, Tolga O, Kamoun, S., Kamoun, Sophien, van Damme, M., Jones, A.M.E., Sklenar, Jan, Sophien Kamoun (6132), Cakir, C., Schornack, S., Schornack, Sebastian, van Damme, Mireille, Jan Sklenar (142122), Jones, Alexandra ME, Jones, Alexandra M., Mireille van Damme (142110), Tolga O. Bozkurt (142114), Bozkurt, Tolga O., Sophien Kamoun, Bozkurt, T.O., Sklenar, J., Alexandra M. E. Jones (50010), Alexandra M E Jones, Damme, M., van, Sebastian Schornack (142120), Jan Sklenar   +30 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

DEVELOPMENT OF EXPERIMENTAL AND COMPUTATIONAL TOOLS FOR THE DESIGN OF VISUAL FORCE FEEDBACK FOCUSED COMPLIANT MECHANISM-BASED END-EFFECTORS

, 2023
Minimally Invasive Robotic Surgery (MIRS) has revolutionized the way modern surgery is conducted by allowing for smaller incisions, finer control, reduced pain, and faster recovery.
Duncan Joseph Isbister (15339403)
core   +1 more source

Cytokinin transfer by a free-living mirid to Nicotiana attenuata recapitulates a strategy of endophytic insects

eLife, 2018
Endophytic insects provide the textbook examples of herbivores that manipulate their host plant’s physiology, putatively altering source/sink relationships by transferring cytokinins (CK) to create ‘green islands’ that increase the nutritional value of ...
Christoph Brütting, Cristina Maria Crava, Martin Schäfer, Meredith C Schuman, Stefan Meldau, Nora Adam, Ian T Baldwin   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Population Genome Sequencing of the Scab Fungal Species Venturia inaequalis, Venturia pirina, Venturia aucupariae and Venturia asperata

G3: Genes, Genomes, Genetics, 2019
The Venturia genus comprises fungal species that are pathogens on Rosaceae host plants, including V. inaequalis and V. asperata on apple, V. aucupariae on sorbus and V. pirina on pear. Although the genetic structure of V.
Bruno Le Cam, Dan Sargent, Jérôme Gouzy, Joëlle Amselem, Marie-Noëlle Bellanger, Olivier Bouchez, Spencer Brown, Valérie Caffier, Marie De Gracia, Robert Debuchy, Ludovic Duvaux, Thibaut Payen, Mélanie Sannier, Jason Shiller, Jérôme Collemare, Christophe Lemaire   +15 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An array of Zymoseptoria tritici effectors suppress plant immune responses [PDF]

Zymoseptoria tritici is the most economically significant fungal pathogen of wheat in Europe. However, despite the importance of this pathogen, the molecular interactions between pathogen and host during infection are not well understood.
Guerreiro, Marco, Abukhalaf, M., Ali, H., Kanyuka, K., Krasileva, K. V., Stukenbrock, E. H., Guerreiro, M. A., Thynne, E., Kanyuka, Kostya, Krasileva, Ksenia V., Kettles, G. J., Kettles, Graeme J., Stukenbrock, Eva, Seong, Kyungyong, Rudd, Jason J., Rudd, Jason, Thynne, Elisha, Salman, Maja J., Krasileva, Ksenia, Guerreiro, Marco A., Salman, Maja, Seong, K., Abukhalaf, Mohammad, Tholey, A., Hansen, R., Salman, M. J., Flores-Nunez, Victor, Kettles, Graeme, Ali, Haider, Bergues, Ana, Bergues, A., Rudd, J. J., Stukenbrock, Eva H., Flores-Nunez, V. M., Tholey, Andreas, Hansen, Rune, Flores‐Nunez, Victor M.   +36 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source