Results 231 to 240 of about 406,957 (282)

Identifying a type of toxic effectors exported by the type VII secretion system to enhance competitive fitness in <i>Streptococcus suis</i>. [PDF]

Front Cell Infect Microbiol
Bai Q, Liu J, Zhao J, Pan X, Zhang Y, Wu Z, Ma J.   +6 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Molecular mechanisms of plant NLR activation and signalling. [PDF]

Plant J
Maruta N, Sorbello M, Garzon-Flores L, Kobe B.   +3 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Expanding the landscape of BREX diversity: uncovering multi-layered functional frameworks and identification of novel BREX-related defense systems. [PDF]

Nucleic Acids Res
Rakesh S, Krishnan A.
europepmc   +1 more source

Diverse haplotypes at a complex Solanum americanum locus confer resistance to Phytophthora infestans and P. capsici

Heal R, Olave-Achury AC, Sindalovskaya M, Long L, Karki HS, Taylor J, Wawryk-Khamdavong A, Bachowska K, Smoker M, Alam M, Pottinger S, Arora V, Sohn K, Witek K, Lin X, Jones JDG.   +15 more
europepmc   +1 more source

Substrate-induced remodeling of protein disordered loops activates Csm DNases. [PDF]

Nucleic Acids Res
Yu Z, Wang F, Zhang Z, Zhang Y, Xu J, Li X, Liang M, Guo J, Ji S, She Q.   +9 more
europepmc   +1 more source

How transcriptional networks control Verticillium plants infection. [PDF]

PLoS Pathog
Chen YY, Harting R, Braus GH.
europepmc   +1 more source

Structural and functional insights into Pseudomonas aeruginosa's secretion systems 1-6: regulation, role in microbial keratitis and drug targets. [PDF]

Eur J Clin Microbiol Infect Dis
Akter T, Challita PM, Haider AM, Islam S, Fatema K, Stapleton F, Willcox M.   +6 more
europepmc   +1 more source