Results 11 to 20 of about 103,207 (299)

High-Altitude Extreme Environments Drive Convergent Evolution of Skin Microbiota in Humans and Horses [PDF]

Microorganisms
Unique skin microbial communities have been shaped by the harsh climatic conditions in high-altitude areas, such as intense ultraviolet radiation and low oxygen concentration.
Yuwei Zhang, Manyu Zhang, Zhengge Zhao, Yunjuan Peng, Feilong Deng, Hui Jiang, Meimei Zhang, Bo Song, Jae Kyeom Kim, Jeong Hoon Pan, Jianmin Chai, Ying Li   +11 more
doaj   +2 more sources

The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition.

PLoS ONE, 2010
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions ...
Lindsay M Edwards, Andrew J Murray, Damian J Tyler, Graham J Kemp, Cameron J Holloway, Peter A Robbins, Stefan Neubauer, Denny Levett, Hugh E Montgomery, Mike P Grocott, Kieran Clarke, Caudwell Xtreme Everest Research Group   +11 more
doaj   +11 more sources

Disparities in COVID-19 incidence and fatality rates at high-altitude [PDF]

PeerJ, 2023
Background SARS-CoV-2 has affected every demography disproportionately, including even the native highland populations. Hypobaric-hypoxic settings at high-altitude (HA, >2,500 masl) present an extreme environment that impacts the survival of permanent ...
Bilal Ahmed Abbasi, Neha Chanana, Tsering Palmo, Qadar Pasha   +3 more
doaj   +2 more sources

Effect of high altitude on human placental amino acid transport [PDF]

Journal of Applied Physiology, 2020
Women residing at high altitudes deliver infants of lower birth weight than at sea level. Birth weight correlates with placental system A-mediated amino acid transport capacity, and severe environmental hypoxia reduces system A activity in isolated trophoblast and the mouse placenta.
Owen. R. Vaughan, Fredrick Thompson, Ramón. A. Lorca, Colleen G. Julian, Theresa L. Powell, Lorna G. Moore, Thomas Jansson   +6 more
openaire   +2 more sources

Introgressive Hybridization and Hypoxia Adaptation in High-Altitude Vertebrates

Frontiers in Genetics, 2021
In natural populations of animals, a growing body of evidence suggests that introgressive hybridization may often serve as an important source of adaptive genetic variation.
Jay F. Storz, Anthony V. Signore
doaj   +1 more source

Effects of Ascent to High Altitude on Human Antimycobacterial Immunity [PDF]

PLoS ONE, 2013
عدوى السل والمرض والوفيات كلها أقل شيوعًا عند الارتفاعات العالية من الارتفاعات المنخفضة وكان الصعود إلى الارتفاعات العالية موصى به تاريخيًا للعلاج. الآليات المناعية والفطرية الكامنة وراء الارتباط بين الارتفاع والسل غير واضحة. درسنا آثار الارتفاع على المتفطرات والمناعة المضادة للبكتيريا.
Sarah Eisen, Louise Pealing, Robert W Aldridge, Mark J. Siedner, Alejandro Necochea, Inna Leybell, Teresa Valencia, Beatriz Sánchez Herrera, Siouxsie Wiles, Jon S. Friedland, Robert H. Gilman, Carlton A. Evans   +11 more
openaire   +8 more sources

Impact of High-Altitude Hypoxia on Bone Defect Repair: A Review of Molecular Mechanisms and Therapeutic Implications

Frontiers in Medicine, 2022
Reaching areas at altitudes over 2,500–3,000 m above sea level has become increasingly common due to commerce, military deployment, tourism, and entertainment.
Pei Chen, Yushan Liu, Wenjing Liu, Yarong Wang, Ziyi Liu, Mingdeng Rong   +5 more
doaj   +1 more source

Lower obesity rate during residence at high altitude among a military population with frequent migration: a quasi experimental model for investigating spatial causation. [PDF]

PLoS ONE, 2014
We sought to evaluate whether residence at high altitude is associated with the development of obesity among those at increased risk of becoming obese. Obesity, a leading global health priority, is often refractory to care.
Jameson D Voss, David B Allison, Bryant J Webber, Jean L Otto, Leslie L Clark   +4 more
doaj   +1 more source

Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans. [PDF]

, 2016
Ventilatory acclimatization to hypoxia is a time-dependent increase in ventilation and the hypoxic ventilatory response (HVR) that involves neural plasticity in both carotid body chemoreceptors and brainstem respiratory centers.
Antonova, Julie, Basaran, Kemal Erdem, Ellis, Erika, Ho, Baran, Hopkins, Susan R, Powell, Frank L, Villongco, Michael, Zarndt, Rachel   +7 more
core   +6 more sources

The dependence of maximum oxygen uptake and utilization (V̇O2max) on hemoglobin‐oxygen affinity and altitude

Physiological Reports, 2023
Oxygen transport from the lungs to peripheral tissue is dependent on the affinity of hemoglobin for oxygen. Recent experimental data have suggested that the maximum human capacity for oxygen uptake and utilization (V̇O2max) at sea level and altitude ...
Kevin L. Webb, Michael J. Joyner, Chad C. Wiggins, Timothy W. Secomb, Tuhin K. Roy   +4 more
doaj   +1 more source