Results 41 to 50 of about 4,635,333 (255)

Therapeutic Potential of Bioactive Compounds from Traditional Chinese Medicine in Modulating Macrophage Cholesterol Metabolism for Atherosclerosis Treatment

Pharmaceuticals
Atherosclerosis (AS) is a complex pathological process characterized by the pivotal involvement of foam cells in its pathogenesis. As the primary cellular components of arterial plaques, foam cells critically determine plaque stability. Foam cells derive
Lijiao Yan, Jiageng Guo, Dan Huang, Fan Zhang, Zhengcai Du, Xiaotao Hou, Jiagang Deng, Yan Xie, Erwei Hao   +8 more
doaj   +1 more source

Isoquercitrin Attenuates Osteogenic Injury in MC3T3 Osteoblastic Cells and the Zebrafish Model via the Keap1-Nrf2-ARE Pathway

Molecules, 2022
Isoquercitrin (IQ) widely exists in natural products, with a variety of pharmacological activities. In this study, the anti-apoptotic and antioxidative activities of IQ were evaluated.
Xue Li, Dongyue Zhou, Di Yang, Yunhua Fu, Xingyu Tao, Xuan Hu, Yulin Dai, Hao Yue   +7 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Insights from Traditional Chinese Medicine for Restoring Skin Barrier Functions

Pharmaceuticals
The skin barrier is essential for maintaining the body’s internal homeostasis, protecting against harmful external substances, and regulating water and electrolyte balance.
Jieyi Yang, Jiageng Guo, Peiling Tang, Shidu Yan, Xiaodong Wang, Huaying Li, Jinling Xie, Jiagang Deng, Xiaotao Hou, Zhengcai Du, Erwei Hao   +10 more
doaj   +1 more source

"I didn't always perceive myself as a science person": Examining efficacy for primary science teaching [PDF]

, 2012
Teacher efficacy has become an important field of research especially in subjects teachers may find challenging, such as science. This study investigates the sources of teachers’ efficacy for teaching science in primary schools in the context of ...
Mansfield, C., Mansfield, Caroline F, Woods-McConney, A., Woods-McConney, Amanda   +3 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Infectious Diseases of Poverty, 2018
Background In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of artemisinin derivatives.
Kazeem Akano, Godwin Ntadom, Chimere Agomo, Christian T. Happi, Onikepe A. Folarin, Grace O. Gbotosho, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Sikiru Amoo, Nnenna Ezeigwe, Stephen Oguche, Bayo Fatunmbi, Akintunde Sowunmi   +19 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Cathepsin B-Oriented Screening, Isolation, and Antitumor Validation of Bioactive Metabolites from Sargassum polycystum

Marine Drugs
Marine medicinal algae represent a valuable reservoir of bioactive metabolites for anticancer drug discovery, yet the efficient identification of target-relevant compounds from chemically complex marine matrices remains challenging.
Wanchao Hou, Lingqiu Zhang, Kai Yu, Jinhua Lu, Congyao Qin, Minmin Qin, Xiuqing Xu, Zhengcai Du, Erwei Hao, Jiagang Deng, Xiaotao Hou   +10 more
doaj   +1 more source

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières. [PDF]

, 2008
Jean-Paul Guthmann and colleagues describe the output of MSF's work in antimalarial efficacy assessment during the last ...
Comte, Eric, Legros, Dominique, Francesco Checchi, Philippe J Guerin, Balkan Suna, Kindermans Jean-Marie, van den Broek Ingrid, Guerin Philippe J, van Herp, Michel, van den Broek, Ingrid, Checchi, Francesco, Ingrid van den Broek, Oscar Bernal, Guerin, Philippe J, Jean-Marie Kindermans, Dominique Legros, Jean-Paul Guthmann, Comte Eric, Michel van Herp, Guthmann Jean-Paul, Venis Sarah, Sarah Venis, Kindermans, Jean-Marie, van Herp Michel, Checchi Francesco, Guthmann, Jean-Paul, Legros Dominique, Eric Comte, Guerin, Philippe, Venis, Sarah, Suna Balkan, Bernal Oscar, Balkan, Suna, Bernal, Oscar   +33 more
core   +1 more source