Results 131 to 140 of about 4,250,837 (304)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Families of Linear Efficiency Programs based on Debreu's Loss Function [PDF]

Gerard Debreu introduced a well known radial efficiency measure which he called a “coefficient of resource utilization.†He derived this scalar from a much less well known “dead loss†function that characterizes the monetary value sacrificed to ...
C.A. Knox Lovell, Juan Aparicioc, Jesús T. Pastora   +2 more
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

National Action Plan for Energy Efficiency [PDF]

, 2006
This report presents policy recommendations for creating a national commitment to energy efficiency through gas and electric utilities, utility regulators, and partner ...
National Action Plan for Energy Efficiency (U.S.)
core  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Sleep Efficiency and Sleep Onset Latency in One Saskatchewan First Nation

Clocks & Sleep
Background: Sleep efficiency and sleep onset latency are two measures that can be used to assess sleep quality. Factors that are related to sleep quality include age, sex, sociodemographic factors, and physical and mental health status.
Chandima P. Karunanayake, Punam Pahwa, Shelley Kirychuk, Mark Fenton, Vivian R. Ramsden, Jeremy Seeseequasis, Warren Seesequasis, Robert Skomro, Donna C. Rennie, Kathleen McMullin, Brooke P. Russell, Niels Koehncke, Sylvia Abonyi, Malcolm King, James A. Dosman   +14 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Comprehensive Analysis and Development of a Bidirectional DC-DC Converter With Improved Voltage Gain and Reduced Stress on Semiconductors

IEEE Open Journal of Power Electronics
This paper initially evaluates the cells of bidirectional converter sections, proposing a new cell that can achieve greater voltage gain and reduce stress on semiconductors. After validating these characteristics, a bidirectional DC-DC converter topology
Fabiano Gonzales Nimitti, Antonio Manuel Santos Spencer Andrade   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source