Results 11 to 20 of about 64 (62)

Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis. [PDF]

Aging Cell
Epigenetic DNA methylation‐based (DNAm) clocks, particularly GrimAge epigenetic age acceleration, outperform telomere length in predicting mortality across three US cohorts. Using Additive Bayesian Networks, we uncovered complex links among biological aging markers, sex, race, and mortality risk, highlighting the utility of DNAm‐based biomarkers in ...
Beydoun MA, Noren Hooten N, Asefa NG, Georgescu MF, Song M, Beydoun HA, Banerjee S, Khubchandani J, Meirelles O, Launer LJ, Evans MK, Zonderman AB.   +11 more
europepmc   +2 more sources

Roles of non‐coding RNAs in eye development and diseases

WIREs RNA, Volume 14, Issue 5, September/October 2023., 2023
ncRNAs participate in different ocular diseases and eye development. Abstract The prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age‐related macular degeneration, and diabetic retinopathy.
Xinrui Shi, Zhengbo Xue, Kaicheng Ye, Jian Yuan, Yan Zhang, Jia Qu, Jianzhong Su   +6 more
wiley   +1 more source

COGNITION, OPTIMISM, AND THE FORMATION OF AGE‐DEPENDENT SURVIVAL BELIEFS

International Economic Review, Volume 62, Issue 2, Page 887-918, May 2021., 2021
Abstract This article investigates the roles of psychological biases for deviations between subjective survival beliefs (SSBs) and objective survival probabilities. We model these deviations through age‐dependent inverse S‐shaped probability weighting functions.
Nils Grevenbrock, Max Groneck, Alexander Ludwig, Alexander Zimper   +3 more
wiley   +1 more source

Stratigraphic drilling in the era of EFTF: The Barnicarndy 1 and NDI Carrara 1 wells.

, 2021
Exploring for the Future (EFTF) is an Australian Government initiative that gathers new data and information about potential mineral, energy and groundwater resources.
Dot Close, Lidena Carr, Emmanuelle Grosjean, Amber J.M. Jarrett, Jade Anderson, Christine Edgoose, Peter W. Haines, Paul A. Henson, Kamal Khider, Liuqi Wang, Adam H.E. Bailey, Susannah MacFarlane, Leon Normore, Chris Carson, Dianne Edwards, Chris Southby   +15 more
core   +1 more source

Transcriptome analysis of the zebrafish atoh7−/− Mutant, lakritz, highlights Atoh7‐dependent genetic networks with potential implications for human eye diseases

FASEB BioAdvances, Volume 2, Issue 7, Page 434-448, July 2020., 2020
Abstract Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing ATOH7 as a retinal disease gene. Remarkably, such studies uncovered ATOH7 variants associated with global eye defects including optic ...
Giuseppina Covello, Fernando J. Rossello, Michele Filosi, Felipe Gajardo, Anne‐Laure Duchemin, Beatrice F. Tremonti, Michael Eichenlaub, Jose M. Polo, David Powell, John Ngai, Miguel L. Allende, Enrico Domenici, Mirana Ramialison, Lucia Poggi   +13 more
wiley   +1 more source

Lithospheric resistivity structures and mineral prospectivity from AusLAMP data in northern Australia

, 2021
Magnetotelluric (MT) data allow geoscientists to investigate the link between mineralisation and lithospheric-scale features and processes. In particular, the highly conductive structures imaged by MT data appear to map the pathways of large-scale palaeo-
Jingming Duan, Darren Kyi, Alison Kirkby, Wenping Jiang, Michael Doublier   +4 more
core   +1 more source

Fragment‐Based Drug Discovery of Novel High‐affinity, Selective, and Anti‐inflammatory Inhibitors of the Keap1‐Nrf2 Protein‐Protein Interaction

Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.
We developed potent and selective noncovalent Keap1‐Nrf2 inhibitors through a structure‐guided fragment‐based approach. These nanomolar inhibitors activate Nrf2‐controlled genes, suppress inflammation via NLRP3 and STING pathways, and exhibit distinct transcriptional profiles compared to covalent Nrf2 activators, offering promising chemical probes and ...
Chunyu Lin, Dilip Narayanan, Marilia Barreca, Cecilie Poulsen, Leandro Silva da Costa, Xiangrong Chen, Kendall G. Wichman, Cherisse A. Charley, Jaslin L. Lindsay, Mahya Dezfouli, Dimitra Vlissari, Thomas S. Mortensen, Camilla B. Chan, Jingyi Wang, William Richardson, Charlotte E. Manning, Zhuoyao Chen, Jie Zang, Helena Käck, Michael Gajhede, Alex N. Bullock, David J. Blake, David Olagnier, Anders Bach   +23 more
wiley   +2 more sources

Research on the joint fluctuation laws between locational marginal price and renewables based on complex networks: A case study in Independent System Operator New England

Energy Science &Engineering, Volume 7, Issue 6, Page 2866-2883, December 2019., 2019
Complex network theory is adopted to provide a statistical perspective rather than a causal perspective for study. Coarse‐grained method is conducted to simplify multiple time series into joint fluctuation patterns, which is different from traditional autoregressive and regression analysis.
Ding Liu, Cunbin Li, Defu Zhao, Qiqing Wang   +3 more
wiley   +1 more source

Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering

Stem Cells International, Volume 2019, Issue 1, 2019., 2019
Retinal degeneration is an irreversible phenomenon caused by various disease conditions including age‐related macular degeneration (AMD) and retinitis pigmentosa (RP). During the course of these diseases, photoreceptors (PRs) are susceptible to degeneration due to their malfunctions or to a primary dysfunction of the retinal pigment epithelium (RPE ...
Karim Ben M’Barek, Christelle Monville, Patricia Murray   +2 more
wiley   +1 more source

Generation of Retinal Organoids with Mature Rods and Cones from Urine‐Derived Human Induced Pluripotent Stem Cells

Stem Cells International, Volume 2018, Issue 1, 2018., 2018
Urine cells, a body trash, have been successfully reprogrammed into human induced pluripotent stem cells (U‐hiPSCs) which hold a huge promise in regenerative medicine. However, it is unknown whether or to what extent U‐hiPSCs can generate retinal cells so far.
Guilan Li, Bingbing Xie, Liwen He, Tiancheng Zhou, Guanjie Gao, Shengxu Liu, Guangjin Pan, Jian Ge, Fuhua Peng, Xiufeng Zhong, Leonard M. Eisenberg   +10 more
wiley   +1 more source