Results 11 to 20 of about 52 (50)
Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis. [PDF]
Aging CellEpigenetic DNA methylation‐based (DNAm) clocks, particularly GrimAge epigenetic age acceleration, outperform telomere length in predicting mortality across three US cohorts. Using Additive Bayesian Networks, we uncovered complex links among biological aging markers, sex, race, and mortality risk, highlighting the utility of DNAm‐based biomarkers in ...
Beydoun MA +11 more
europepmc +2 more sources
Roles of non‐coding RNAs in eye development and diseases
WIREs RNA, Volume 14, Issue 5, September/October 2023., 2023 ncRNAs participate in different ocular diseases and eye development. Abstract The prevalence of ocular disorders is dramatically increasing worldwide, especially those that cause visual impairment and permanent loss of vision, including cataract, glaucoma, age‐related macular degeneration, and diabetic retinopathy.
Xinrui Shi +6 more
wiley +1 more source
COGNITION, OPTIMISM, AND THE FORMATION OF AGE‐DEPENDENT SURVIVAL BELIEFS
International Economic Review, Volume 62, Issue 2, Page 887-918, May 2021., 2021 Abstract This article investigates the roles of psychological biases for deviations between subjective survival beliefs (SSBs) and objective survival probabilities. We model these deviations through age‐dependent inverse S‐shaped probability weighting functions.
Nils Grevenbrock +3 more
wiley +1 more source
FASEB BioAdvances, Volume 2, Issue 7, Page 434-448, July 2020., 2020 Abstract Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing ATOH7 as a retinal disease gene. Remarkably, such studies uncovered ATOH7 variants associated with global eye defects including optic ...
Giuseppina Covello +13 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.We developed potent and selective noncovalent Keap1‐Nrf2 inhibitors through a structure‐guided fragment‐based approach. These nanomolar inhibitors activate Nrf2‐controlled genes, suppress inflammation via NLRP3 and STING pathways, and exhibit distinct transcriptional profiles compared to covalent Nrf2 activators, offering promising chemical probes and ...
Chunyu Lin +23 more
wiley +2 more sources
Energy Science &Engineering, Volume 7, Issue 6, Page 2866-2883, December 2019., 2019 Complex network theory is adopted to provide a statistical perspective rather than a causal perspective for study. Coarse‐grained method is conducted to simplify multiple time series into joint fluctuation patterns, which is different from traditional autoregressive and regression analysis.
Ding Liu +3 more
wiley +1 more source
Stem Cells International, Volume 2019, Issue 1, 2019., 2019 Retinal degeneration is an irreversible phenomenon caused by various disease conditions including age‐related macular degeneration (AMD) and retinitis pigmentosa (RP). During the course of these diseases, photoreceptors (PRs) are susceptible to degeneration due to their malfunctions or to a primary dysfunction of the retinal pigment epithelium (RPE ...
Karim Ben M’Barek +2 more
wiley +1 more source
Stem Cells International, Volume 2018, Issue 1, 2018., 2018 Urine cells, a body trash, have been successfully reprogrammed into human induced pluripotent stem cells (U‐hiPSCs) which hold a huge promise in regenerative medicine. However, it is unknown whether or to what extent U‐hiPSCs can generate retinal cells so far.
Guilan Li +10 more
wiley +1 more source
New Quantization Approach for the Anomaly: The Increase in Time Float following Consumption
Mathematical Problems in Engineering, Volume 2018, Issue 1, 2018., 2018 Anomalous scenarios in projects with generalized precedence relations (GPRs) have been arousing widely interest. A recent relevant discovery of anomaly under GPRs is that an activity’s time float increases following its consumption. The scenario is contrary to a common idea for plan management, and it also changes relationships between time floats and ...
Zhixiong Su +2 more
wiley +1 more source
Applied Psychology: Health and Well-Being, Volume 17, Issue 1, 25 February 2025.Abstract Accumulating studies have documented strong associations between a higher sense of control and improved health and well‐being outcomes. However, less is known about the determinants of increased sense of control. Our analysis used data from 13,771 older adults in the Health and Retirement Study (HRS)—a diverse, longitudinal, and national study
Eric S. Kim +4 more
wiley +1 more source