Results 101 to 110 of about 785,489 (353)
Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling. [PDF]
, 2015 In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly.
Cavenee, WK +5 more
core
High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer
FEBS Open Bio, EarlyView.Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson +5 more
wiley +1 more source
Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer
Science immunology, 2020 EGFR inhibitor erlotinib synergizes with anti–PD-1 in a mouse model of lung adenocarcinoma. Giving anti–PD-1 a boost Anti–PD-1 therapy is ineffective in the context of EGFR-mutated lung adenocarcinomas (LUADs). Here, Sugiyama et al.
E. Sugiyama +13 more
semanticscholar +1 more source
Targeting the evolution of drug resistance in lung cancer
Molecular & Cellular Oncology, 2019 Even in their intended disease subset, Epithelial Growth Factor Receptor tyrosine kinase inhibitors leave behind residual disease eventually resulting in acquired resistance. Our study indicates that this process is driven by Aurora Kinase A.
Khyati Niral Shah, Sourav Bandyopadhyay
doaj +1 more source
One lithium level >1.0 mmol/L causes an acute decline in eGFR: findings from a retrospective analysis of a monitoring database [PDF]
, 2014 Objectives Lithium is a mainstay of bipolar disorder treatment, however, there are still differences in opinion on the effects of lithium use on renal function.
Anderson, Tim +5 more
core +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Molecular Cancer, 2018 Recent advances in diagnosis and treatment are enabling a more targeted approach to treating lung cancers. Therapy targeting the specific oncogenic driver mutation could inhibit tumor progression and provide a favorable prognosis in clinical practice ...
Shang-Gin Wu, J. Shih
semanticscholar +1 more source
El cáncer de pulmón en mujeres
Arbor: Ciencia, Pensamiento y Cultura, 2015 El cáncer de pulmón es la enfermedad maligna más frecuente en el mundo. En los últimos diez años en España, la mortalidad por cáncer de pulmón ha aumentado un 20% en las mujeres frente a un 5% en los hombres, debido a los cambios recientes de patrones de
Enriqueta Felip
doaj +1 more source
Chinese Journal of Lung Cancer, 2020 While treating cancer, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) still faces inevitable drug resistance. Investigations into the mechanisms which foster resistance to EGFR-TKI has led to the discovery of novel biomarkers and ...
Zitong ZHAO, Yu NI, Li LI, Tao XIN
doaj +1 more source
Inhibiting epidermal growth factor receptor at a distance. [PDF]
, 2014 The epidermal growth factor receptor (EGFR) tyrosine kinase is implicated in a large number of human cancers. Most EGFR inhibitors target the extracellular, growth factor-binding domain or the intracellular, ATP-binding domain. Here we describe molecules
Denton, Elizabeth +2 more
core +2 more sources