Results 101 to 110 of about 132,691 (210)
EGFR T790M: revealing the secrets of a gatekeeper
, 2017 Brian Ko, Daniel Paucar, Balazs Halmos Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA Abstract: Non-small-cell lung cancers that harbor activating mutations in the EGFR gene represent ...
Halmos B, Ko B, Paucar D
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Innovative drug delivery system using EGFR-targeted engineered peptides in anaplastic thyroid cancer treatment [PDF]
, 2023 peer reviewedAbstract: Anaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in humans. Mostly affected signaling pathways in ATC are those of MAP kinase and PIP3/AKT/mTOR. The median survival of patients with ATC
Vandecasteele, Samuel +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Novel mechanism of resistance to targeted therapies in lung cancer
Molecular & Cellular Oncology, 2019 We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang +7 more
wiley +1 more source
Treating EGFR mutation resistance in non-small cell lung cancer – role of osimertinib
, 2017 Valentina Mazza,1 Federico Cappuzzo1,2 1Department of Oncology-Hematology, 2Department of Medical Oncology, AUSL Romagna, Ravenna, Italy Abstract: The discovery of mutations in EGFR significantly changed the treatment paradigm of patients with EGFR ...
Cappuzzo F, Mazza V
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, 2015 Representative PDAC cases with different EGFR/CXCR4 expression profiles: EGFR-/CXCR4− (A), EGFR+/CXCR4− (B), EGFR-/CXCR4+ (C), and EGFR+/CXCR4+ (D). Magnification x 100.
Huanwen Wu (697595) +7 more
core +1 more source
MLN4924: additional activities beyond neddylation inhibition
Molecular & Cellular Oncology, 2019 MLN4924, a small molecular inhibitor of NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) activating enzyme (NAE), blocks cullin neddylation to inactivate cullin-RING ligase. We found that MLN4924 has additional activities:
Qiyin Zhou, Yi Sun
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg +5 more
wiley +1 more source
Synthesis of indolinone-based derivatives for liposomal insertion in active targeting against EGFR.
, 2022 reservedSulla base dei risultati ottenuti a seguito di un precedente progetto di ricerca svolto presso il Dipartimento di Scienze del Farmaco, l'obiettivo di questo lavoro di tesi sperimentale consta nella sintesi di derivati a base indolinonica ...
NEGRI, STEFANO
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