Results 41 to 50 of about 545,624 (314)

Expressions of TP53, PDGF and EGFR in Primary Astrocytomas and Their Correlation with Clinicopathological Features and Prognosis

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the expression of TP53, PDGF and EGFR in primary astrocytomas, and analyze their correlation with clinicopathological features and prognosis.
SUN Xiaoling, ZHANG Xiaojuan, ZHANG Qingquan, QIU Lei, WANG Linna, HOU Suping   +5 more
doaj   +1 more source

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

PLoS Medicine, 2005
Background Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib (Tarceva) usually harbor somatic gain-of-function mutations in exons encoding the kinase domain of the epidermal growth factor ...
W. Pao, V. Miller, K. Politi, Gregory Riely, R. Somwar, M. Zakowski, M. Kris, H. Varmus   +7 more
semanticscholar   +1 more source

Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

Seminars in Cancer Biology, 2020
Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) comprise the vast majority of EGFR ...
Peter T. Harrison, S. Vyse, Paul H. Huang   +2 more
semanticscholar   +1 more source

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2022
Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the
Lei Yang, Yun-Ting He, S. Dong, Xue-Wu Wei, Zhi-hong Chen, Bo Zhang, Weidong Chen, Xiao-Rong Yang, Fen Wang, Xue-Meng Shang, W. Zhong, Yi‐Long Wu, Qing Zhou   +12 more
semanticscholar   +1 more source

pSTAT3 transactivates EGFR in maintaining EGFR protein homeostasis and EGFR-TKI resistance

Acta Biochimica et Biophysica Sinica
EGFR protein trafficking is critical for regulating multiple biological processes, including cell growth and survival. However, how EGFR protein homeostasis is maintained remains unclear. In this study, we show that a reduction in plasma membrane-associated EGFR triggers EGFR transcription by promoting pSTAT3 nuclear localization.
Ao Juan, Fei Junjie, Wang Guoqiang, Zhang Wenhua, Yu Shuhan, Guo Rongtian, Niu Mengmeng, Chen Hu, Cao Yang, Xiao Zhi-Xiong Jim, Yi Yong   +10 more
openaire   +4 more sources

THE IMPORTANCE OF DETERMINING THE UROMODULIN SERUM CONCENTRATION IN DIABETES MELLITUS TYPE 2 PATIENTS

Sanamed, 2021
Introduction: In the kidney, cells in the thick ascending limb of the loop of the Henle synthesized uromodulin (UMOD). This study aims to present the evaluation of the uromodulin serum concentration in diabetes mellitus type 2 (T2DM) patients in the ...
Jordanova Elena, Samardzic Vladimir, Pekovic-Perunicic Gordana, Tica-Jevtic Jelena, Simic-Ogrizovic Sanja   +4 more
doaj   +1 more source

Antitumor Efficacy and Mechanisms of Lapatinib in Combination with Cisplatin on Esophageal Squamous Cancer Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To evaluate the antitumor efficacy of lapatinib in combination with cisplatin on esophageal squamous cell carcinoma (ESCC) and related mechanisms.
DOU Qiaohua, GUO Xiaofang, ZHU Xiaofei, ZHANG Yueyue, YANG Fan   +4 more
doaj   +1 more source

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines ...
Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Xue Zou, Zhixu Zhou, Zhenchao Wang, Guiping Ouyang, Longjia Yan   +9 more
doaj   +1 more source

GENETIC POLYMORPHISM OF RETROPERITONEAL MYXOID LIPOSARCOMA

Сибирский онкологический журнал, 2020
Objective: to detect new molecular genetic markers and therapeutic targets in retroperitoneal myxoid liposarcoma.Material and Methods. DNA samples isolated from tumor tissue and obtained from formalinfixed paraffin-embedded (FFPE) slides were used.
A. Yu. Volkov, V. M. Safronova, S. N. Nered, L. N. Lyubchenko, I. S. Stilidi   +4 more
doaj   +1 more source

Correlation of sonographic parameters with renal function in patients with newly diagnosed chronic kidney disease

Journal of Ultrasonography, 2022
To correlate sonographic renal parameters (mean renal cortical thickness, length and volume) with renal functions in patients with newly diagnosed chronic kidney disease.
Garg Aborishi, Jhobta Anupam, Kapila Sumala, Rathour Devesha   +3 more
doaj   +1 more source