Results 141 to 150 of about 401,950 (315)

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq

Medical Journal of Babylon
Background: There is a need for early and accurate diagnosis of acute kidney injury, as high levels of cystatin C, copeptin, and low apelin levels in serum can provide an early diagnosis of acute kidney injury in patients.
Anwar S. Majeed, Layla A. Mustafa
doaj   +1 more source

Data from Activation of the Aryl Hydrocarbon Receptor Leads to Resistance to EGFR TKIs in Non–Small Cell Lung Cancer by Activating Src-mediated Bypass Signaling

, 2023
Mingxiang Ye, Yong Zhang, Hong‐Jun Gao, Yan Xu, Pengyu Jing, Jianxiong Wu, Xinxin Zhang, Jie Xiong, Chenfang Dong, Libo Yao, Jian Zhang   +10 more
openalex   +1 more source

MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy [PDF]

, 2021
Gavitt A. Woodard, Johannes R. Kratz, Greg J. Haro, Matthew A. Gubens, C. Blakely, Kirk D. Jones, Michael J. Mann, David M. Jablons   +7 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Correlation between Expression of EGFR and the Prognosis of Patients with Cervical Carcinoma

, 2002
Young Tae Kim, Sang‐Won Park, Jae Wook Kim   +2 more
openalex   +2 more sources

Data from The Impact of <i>EGFR</i> T790M Mutations and <i>BIM</i> mRNA Expression on Outcome in Patients with <i>EGFR</i>-Mutant NSCLC Treated with Erlotinib or Chemotherapy in the Randomized Phase III EURTAC Trial

, 2023
Carlota Costa, Miguel Angel Molina, Ana Drozdowskyj, Ana Giménez‐Capitán, Jordi Bertran-Alamillo, Niki Karachaliou, Radj Gervais, Bartomeu Massutí, Wei Jia, Teresa Morán, Margarita Majem, Enriqueta Felip, Enric Carcereny, Rosario García‐Campelo, Santiago Viteri, Miquel Tarón, Mayumi Ono, Petros Giannikopoulos, Trever G. Bivona, Rafael Rosell   +19 more
openalex   +1 more source

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Impact of CD151 overexpression on prognosis and therapy in non‐small cell lung cancer patients lacking EGFR mutations [PDF]

Amanda Huee‐Ping Wong, Min En Nga, Chin Yein Chin, Yee Kit Tai, Hung Chew Wong, Ross A. Soo, Ömer An, Henry Yang, Ju Ee Seet, Yaw Chyn Lim, John Kit Chung Tam, Thai Tran   +11 more
openalex   +1 more source

Supplemental Figure S1 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma

, 2023
Jill Wykosky, Jingjing Hu, German G. Gomez, Tiffany Taylor, Genaro R. Villa, Donald Pizzo, Scott R. VandenBerg, Amy Haseley Thorne, Clark C. Chen, Paul S. Mischel, Steven L. Gonias, Webster K. Cavenee, Frank B. Furnari   +12 more
openalex   +1 more source