Advanced Science, EarlyView.Early thoracic lesions are already heavily infiltrated by immune cells, yet these infiltrates largely consist of bystander T lymphocytes within an immunosuppressive microenvironment. Pathological invasion is strikingly associated with the neogenesis of T/B cell‐rich TLSs that predominantly remain immature.
Pengfei Ma +20 more
wiley +1 more source
Anemia and Red-Cell Size Across Estimated Glomerular Filtration Rate in a Hospital Laboratory Cohort. [PDF]
J Clin MedMadkhali Y.
europepmc +1 more source
Annals of Gastroenterological Surgery, EarlyView.KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda +9 more
wiley +1 more source
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials. [PDF]
J Gastrointest CancerKazmi SK +5 more
europepmc +1 more source
Annals of Gastroenterological Surgery, EarlyView.Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley +1 more source
Primary resistance to afatinib in a patient with NSCLC harboring <i>EGFR</i> p.E709_T710delinsD and brain metastases: a case report and literature review. [PDF]
Front OncolDong SS, Zhang X, Dong W.
europepmc +1 more source
Outcomes of Patients With AL Amyloidosis and End‐Stage Renal Disease After Initiation of Therapy
American Journal of Hematology, EarlyView.ABSTRACT In AL amyloidosis, advanced renal disease can impact treatment options and cause significant morbidity. Patients with ESRD requiring dialysis are a group with currently unmet needs. In this collaborative study, we identified 362 patients from three European centers who initiated dialysis during the course of the disease.
Foteini Theodorakakou +10 more
wiley +1 more source
Risk factors and time-to-event prediction of brain metastasis in patients with lung adenocarcinoma: a retrospective cohort study. [PDF]
Front GenetWang J, Shen Y, Xu Y, Liu J, Guo Y.
europepmc +1 more source
Construction Trade Work Is Associated With Accelerated Decline in Kidney Function
American Journal of Industrial Medicine, EarlyView.ABSTRACT Background Construction workers are exposed to airborne particulates, organic solvents, and metals—agents linked to elevated risk of chronic kidney disease (CKD). Few studies have evaluated whether construction trade work is associated with longitudinal changes in estimated glomerular filtration rate (eGFR), a key indicator of kidney function.
Sammy Almashat +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low +11 more
wiley +2 more sources