Results 11 to 20 of about 785,489 (353)

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells [PDF]

, 2015
Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple cellular processes including proliferation, differentiation, cell migration and cell survival ...
Cardinali, Beatrice, FUSTAINO, VALENTINA, GIANNINI, Giuseppe, LALLI, CRISTIANA, Papoff, Giuliana, PRESUTTI, DARIO, Ruberti, Giovina, Samperna, Simone, Santini, Simonetta   +8 more
core   +15 more sources

Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer

Nature Communications, 2023
Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), potently and selectively inhibits EGFR-TKI-sensitizing and EGFR T790M resistance mutations.
J. Chmielecki, J. Gray, Ying Cheng, Y. Ohe, F. Imamura, B. Cho, Meng-Chih Lin, M. Majem, R. Shah, Y. Rukazenkov, A. Todd, A. Markovets, J. Barrett, R. Hartmaier, S. Ramalingam   +14 more
semanticscholar   +1 more source

Amivantamab in EGFR Exon 20 Insertion–Mutated Non–Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study

Journal of Clinical Oncology, 2021
PURPOSE Non–small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion (Exon20ins) mutations exhibits inherent resistance to approved tyrosine kinase inhibitors.
Keunchil Park, E. Haura, N. Leighl, P. Mitchell, C. Shu, N. Girard, S. Viteri, Ji-Youn Han, Sang-We Kim, C. Lee, J. Sabari, A. Spira, Tsung-Ying Yang, Dong-Wan Kim, K. Lee, R. Sanborn, J. Trigo, K. Goto, Jong-Seok Lee, J. Yang, R. Govindan, J. Bauml, P. Garrido, M. Krebs, K. Reckamp, John Xie, J. Curtin, N. Haddish-Berhane, A. Roshak, D. Millington, Patricia A. Lorenzini, M. Thayu, R. Knoblauch, B. Cho   +33 more
semanticscholar   +1 more source

Small Molecule EGFR Inhibitors as Anti-Cancer Agents: Discovery, Mechanisms of Action, and Opportunities

International Journal of Molecular Sciences, 2023
Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a promising therapeutic strategy for the treatment of cancer.
Tanzida Zubair, D. Bandyopadhyay
semanticscholar   +1 more source

Biomarkers to target and silence stemness of breast cancer stem cell model: silencing MDR1 by siRNA

Türk Biyokimya Dergisi, 2022
Aim of the study was to reveal new biomarker genes to target breast cancer stem-like cells (BCSC-like) and then sensitize BCSC-like cells to chemotherapy by silencing MDR1 gene found to be the most suitable target.
Yıldırım Gamze, Kars Meltem D., Kars Gökhan, Kılıç Hamdi Ş.   +3 more
doaj   +1 more source

Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

Journal of Hematology & Oncology, 2022
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the preferential options for advanced non-small cell lung cancer (NSCLC) patients harboring EGFR mutations.
Kai Fu, Fa Xie, Fang Wang, Liwu Fu
semanticscholar   +1 more source

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Cells, 2020
Hydrophobic bile salts are considered to promote liver fibrosis in cholestasis. However, evidence for this widely accepted hypothesis remains scarce. In established animal models of cholestasis, e.g., by Mdr2 knockout, cholestasis and fibrosis are both ...
Simon Hohenester, Veronika Kanitz, Andreas E. Kremer, Coen C. Paulusma, Ralf Wimmer, Helen Kuehn, Gerald Denk, David Horst, Ronald Oude Elferink, Ulrich Beuers   +9 more
doaj   +1 more source

Different levels of epidermal growth factor signaling modifies the differentiation of specific cell types in mouse postnatal retina [PDF]

Archives of Biological Sciences, 2019
Epidermal growth factor (EGF) signaling has been implicated in the regulation of the differentiation and proliferation of retinal progenitors. We assessed how different levels of EGF signaling, achieved either by increasing receptor expression or via ...
Ivković Sanja, Jovanović-Macura Irena, Antonijević Tijana, Kanazir Selma, Henrique Domingos   +4 more
doaj   +1 more source

Divergence between serum creatine and cystatin C in estimating glomerular filtration rate of critically ill COVID-19 patients

Renal Failure, 2021
Background The clinical use of serum creatine (sCr) and cystatin C (CysC) in kidney function evaluation of critically ill patients has been in continuous discussion.
Yanan Liu, Peng Xia, Wei Cao, Zhengyin Liu, Jie Ma, Ke Zheng, Limeng Chen, Xuewang Li, Yan Qin, Xuemei Li   +9 more
doaj   +1 more source

Intratumor heterogeneity of driver mutations and TMB distribution in 30 early-stage LUAD patients with multiple lesions

Frontiers in Oncology, 2022
BackgroundDifferentiating multiple pulmonary lesions as multiple primary lung cancer (MLC) or intra-pulmonary metastasis (IPM) is critical. Lung cancer also has a high genetic heterogeneity, which influenced the treatment strategy.
Yuan Qiu, Yuan Qiu, Liping Liu, Liping Liu, Haihong Yang, Haihong Yang, Hanzhang Chen, Hanzhang Chen, Qiuhua Deng, Qiuhua Deng, Dakai Xiao, Dakai Xiao, Yongping Lin, Yongping Lin, Changbin Zhu, Weiwei Li, Di Shao, Wenxi Jiang, Kui Wu, Jianxing He, Jianxing He   +20 more
doaj   +1 more source