Results 11 to 20 of about 775,670 (354)
Cancer Discovery, 2012 Abstract Erlotinib and gefitinib inhibit the growth of non–small cell lung cancer tumors that harbor activating epidermal growth factor receptor (EGFR) mutations but are ineffective against EGFR variants found in glioblastoma. New studies by Barkovich and colleagues and Vivanco and colleagues show that these drugs only occupy the active ...
Jin H, Park, Mark A, Lemmon
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Clinical Journal of the American Society of Nephrology, 2009 GFR is the accepted metric for evaluating renal function but measuring it directly (mGFR) can be cumbersome, time-consuming, and costly. The constant infusion method using inulin as the filtration marker, introduced in 1934 by Richards and Smith (1), has undergone many revisions that have now made mGFR easier to perform, although not widely available ...
Richard J. Glassock +1 more
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Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas [PDF]
Clinical Cancer Research, 2021 Abstract Purpose: Gastric and gastroesophageal adenocarcinomas represent the third leading cause of cancer mortality worldwide. Despite significant therapeutic improvement, the outcome of patients with advanced gastroesophageal adenocarcinoma is poor. Randomized clinical trials failed to show a
Simona Corso +41 more
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Identification of the zinc finger 216 (ZNF216) in human carcinoma cells. A potential regulator of EGFR activity [PDF]
, 2016 Epidermal Growth Factor Receptor (EGFR), a member of the ErbB family of receptor tyrosine kinase (RTK) proteins, is aberrantly expressed or deregulated in tumors and plays pivotal roles in cancer onset and metastatic progression.
Calogero, Antonella +10 more
core +8 more sources
Water-soluble pristine C60 fullerene attenuates acetaminophen-induced liver injury [PDF]
BioImpacts, 2019 Introduction: Oxidative stress has been suggested as the main trigger and pathological mechanism of toxic liver injury. Effects of powerful free radical scavenger С60 fullerene on rat liver injury and liver cells (HepG2 line) were aimed to be discovered.
Halyna Kuznietsova +6 more
doaj +1 more source
EGFR signaling pathway as therapeutic target in human cancers.
Seminars in Cancer Biology, 2022 Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand orchestrator of epithelial transformation, and hence one of the most world-wide studied ...
E. Levantini +3 more
semanticscholar +1 more source
Transactivation of EGFR by LPS induces COX-2 expression in enterocytes [PDF]
, 2012 Necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal morbidity and mortality in preterm infants. NEC is characterized by an exaggerated inflammatory response to bacterial flora leading to bowel necrosis.
A Grishin +45 more
core +7 more sources
EGFR‐AS1 Promotes Bladder Cancer Progression by Upregulating EGFR [PDF]
BioMed Research International, 2020 Long noncoding RNAs play an essential role in bladder cancer progression. The role of long noncoding RNA EGFR‐AS1 in bladder cancer needs further study. We used clinical specimens to analyze the relationship between EGFR‐AS1 and bladder cancer patients’ characteristics.
Anbang Wang +8 more
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EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance
Cancers, 2021 Simple Summary Growth factors are hormone-like molecules able to promote division and migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor growth and metastasis. Here we review the epidermal growth factor (EGF), which
M. L. Uribe, Ilaria Marrocco, Y. Yarden
semanticscholar +1 more source
Structure-based classification predicts drug response in EGFR-mutant NSCLC
Nature, 2021 Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)1–3.
J. Robichaux +32 more
semanticscholar +1 more source