Results 201 to 210 of about 401,950 (315)

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
ABSTRACT Bone angiogenesis is important for bone formation and regeneration after bone injury. Endothelial‐derived angiogenic factors are key signal transducers in the bone microenvironment and maintain vascular–osteogenic coupling during bone regeneration.
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer. [PDF]

Theranostics
Yan Y, Shang J, Liu C, Chen Y, Bao Y, Zhao Y, Fan F, Sun Y, Zhou Y, Wu Y, Wang Y, Han H, Chen H, Pan Y.   +13 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Serum markers for prognostic value of EGFR-TKI in lung adenocarcinoma with bone metastases: a retrospective study. [PDF]

PeerJ
Li J, Wang S, Deng Z, Zhang L, Liu M, Luo Y, Guo Y, Liu P, Liu C.   +8 more
europepmc   +1 more source

EP.12A.30 Landscape of EGFR Mutations and Real-World Experience of Therapeutic Interventions - A Community Oncology Study [PDF]

Kunal Jobanputra, V. Maniar, U. Maheshwari, Disha Morzaria, Amit Joshi, P. Kalaskar, Khashti Ballabh Joshi, M. Randive, M. Mekha, Nitin Bayas, Pradip Kendre, S. Dhande, Akshay Shivchhand, Chandrashekhar Pethe, Dilipkumar Pal, Krushna Chaudhari   +15 more
openalex   +1 more source

Impact of Renin‐Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen, Ryo Seishima, Masayoshi Monno, Satoru Morita, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa   +6 more
wiley   +1 more source

Therapeutic progress in leptomeningeal metastasis from EGFR mutant non-small cell lung cancer: a clinical medicine review. [PDF]

J Cancer Res Clin Oncol
Ding T, Xie Y, Ding M.
europepmc   +1 more source

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

EGFR activation requires cholesterol interaction at the inner leaflet of the plasma membrane. [PDF]

Sci Adv
Kim DH, Hong MT, Bocharov EV, Park S, Bershatsky YV, Volynsky PE, Kim E, Efremov RG, Cho W, Park SY, Ryu SH.   +10 more
europepmc   +1 more source

EGFR Negative [PDF]

, 2020
openaire   +1 more source