Results 201 to 210 of about 775,670 (354)

Active regulation of the epidermal growth factor receptor by the membrane bilayer. [PDF]

Elife
Srinivasan S, Lin X, Chen X, Regmi R, Zhang B, Schlau-Cohen GS.   +5 more
europepmc   +1 more source

EGFR [PDF]

, 2019
openaire   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Revisiting Biomarker-Guided Therapy in EGFR-Mutant Non-Small Cell Lung Cancer with High PD-L1 Expression. [PDF]

Int J Mol Sci
Park N, Cho Y, Zheng HM, Ryu WK, Jung KH, Lim JH.   +5 more
europepmc   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Influence of Decreased Kidney Function on Plasma Biomarkers of Neurodegenerative Disorders in Routine Care: Confirmation of the Interest of Ratios. [PDF]

Neurology
Mondésert E, Cristol JP, Bargnoux AS, Duchiron M, Busto GU, Hirtz C, Barnier-Figue G, Perrein F, Turpinat C, Jurici S, Gabelle A, Bennys K, Lehmann S, Delaby C.   +13 more
europepmc   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR. [PDF]

J Extracell Biol
Pishavar E, Shojaei-Ghahrizjani F, Meehan B, Tawil N, Spinelli C, Choi D, Wong FC, Jalali M, Rak J.   +8 more
europepmc   +1 more source

AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer.

New England Journal of Medicine, 2015
P. Jänne, J. Yang, Dong-Wan Kim, D. Planchard, Y. Ohe, S. Ramalingam, M. Ahn, Sang-We Kim, W. Su, L. Horn, D. Haggstrom, E. Felip, Joo‐Hang Kim, P. Frewer, M. Cantarini, K. Brown, P. Dickinson, S. Ghiorghiu, M. Ranson   +18 more
semanticscholar   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source