Results 241 to 250 of about 785,489 (353)

EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis

open access: yesClinical Cancer Research, 2016
J. Gainor   +20 more
semanticscholar   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

open access: yesAdvanced Science, EarlyView.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei   +8 more
wiley   +1 more source

Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial

open access: hybrid
Jonathan W. Goldman   +16 more
openalex   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui   +10 more
wiley   +1 more source

Determination of p53 Mutations, EGFR Overexpression, and Loss of p16 Expression in Pediatric Glioblastomas [PDF]

open access: bronze, 1997
Ulrich Sure   +6 more
openalex   +1 more source

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