Results 241 to 250 of about 775,670 (354)

EGFR Negative [PDF]

, 2020
openaire   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Interaction between oxygen saturation and renal function on 30-day mortality in emergency department patients. [PDF]

Sci Rep
Zwawi A, Swärd P, Forsberg F, Melander O, Ekelund U, Björkelund A, Wändell P, Carlsson AC, Ruge T.   +8 more
europepmc   +1 more source

EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis

Clinical Cancer Research, 2016
J. Gainor, A. Shaw, L. Sequist, Xiujun Fu, C. Azzoli, Z. Piotrowska, Tiffany Huynh, Ling Zhao, L. Fulton, Katherine R. Schultz, Emily Howe, A. Farago, R. Sullivan, J. Stone, S. Digumarthy, T. Morán, A. Hata, Yukako Yagi, B. Yeap, J. Engelman, M. Mino‐Kenudson   +20 more
semanticscholar   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, EarlyView.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancer. [PDF]

Sci Rep
Yang L, Bhattacharya A, Li Y, Peterson D, Zhang Y.   +4 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Impact of Different Glomerular Filtration Rate Equations on Metformin Eligibility in Patients with Diabetes Mellitus and Chronic Kidney Disease. [PDF]

J Clin Med
Traiwanatham S, Jantarapootirat M, Thammavaranucupt K, Suppadungsuk S, Sriphrapradang C.   +4 more
europepmc   +1 more source

Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors

Annals of Oncology, 2018
D. Westover, J. Zugazagoitia, B. Cho, C. Lovly, L. Paz-Ares   +4 more
semanticscholar   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source