Results 51 to 60 of about 653,031 (357)

Long-term lithium treatment in bipolar disorder. effects on glomerular filtration rate and other metabolic parameters [PDF]

, 2017
.BACKGROUND: Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function.
Abramowicz, Maria, Alda, Martin, Baldessarini, Ross J., Bauer, Michael, Bocchetta, Alberto, Bolzani, Lorenza, Calkin, Cynthia V, Chillotti, Caterina, Hidalgo Mazzei, Diego, Manchia, Mirko, Murru, Andrea, Müller Oerlinghausen, Bruno, Perugi, Giulio, Pinna, Marco, Quaranta, Giuseppe, Reginaldi, Daniela, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K, Saiger, David, SANI, Gabriele, Selle, Valerio, Stamm, Thomas, Tondo, Leonardo, Vázquez, Gustavo H, Veeh, Julia, Vieta, Eduard   +26 more
core   +3 more sources

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines ...
Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Xue Zou, Zhixu Zhou, Zhenchao Wang, Guiping Ouyang, Longjia Yan   +9 more
doaj   +1 more source

GENETIC POLYMORPHISM OF RETROPERITONEAL MYXOID LIPOSARCOMA

Сибирский онкологический журнал, 2020
Objective: to detect new molecular genetic markers and therapeutic targets in retroperitoneal myxoid liposarcoma.Material and Methods. DNA samples isolated from tumor tissue and obtained from formalinfixed paraffin-embedded (FFPE) slides were used.
A. Yu. Volkov, V. M. Safronova, S. N. Nered, L. N. Lyubchenko, I. S. Stilidi   +4 more
doaj   +1 more source

Role of predictable biomarkers in early detection of cardiovascular events in Chronic Kidney Disease III and IV

Current Issues in Pharmacy and Medical Sciences, 2022
This comes about because of a lack of predicted biomarkers in the risk analysis of CVD events in chronic kidney disease (CKD) patients. The present study aimed to determine the clinical utility of independent, predictable biomarkers such as serum ...
Durgaprasad Bhamidipaty Kanaka, Malla Rama Rao, Lahari Bhamidipaty Durgananda, Vijayalakshmi Payala, Guntoory Indira, Kalyan Kolli Viswa   +5 more
doaj   +1 more source

Automatic Classification of Irregularly Sampled Time Series with Unequal Lengths: A Case Study on Estimated Glomerular Filtration Rate

, 2016
A patient's estimated glomerular filtration rate (eGFR) can provide important information about disease progression and kidney function. Traditionally, an eGFR time series is interpreted by a human expert labelling it as stable or unstable.
Bull, Simon, Poh, Norman, Tirunagari, Santosh   +2 more
core   +1 more source

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. [PDF]

, 2016
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous.
David James, C, Engler, Jane R, Ewald, Andrew J, Gong, Henry, Huillard, Emmanuelle, Koshkakaryan, Gayane, Lindberg, Olle R, McKinney, Andrew, Molinaro, Annette M, Phillips, Joanna J, Robinson, Aaron E, Shieh, Joseph T   +11 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The impact of weekly semaglutide, a glucagon-like peptide-1 agonist, on kidney outcomes in adults with type 2 diabetes mellitus

Journal of Family Medicine and Primary Care
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder associated with kidney complications. This study aims to investigate the effects of weekly subcutaneous semaglutide, a GLP-1 agonist, on kidney outcomes.
Ahmad A Algarni, Fahad S Alqarni, Hanin A Shalaby   +2 more
doaj   +1 more source

Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway

Drug Design, Development and Therapy, 2022
Zhen-Ni Liu,1– 3,* Qian-Qian Su,4,* Yu-Hui Wang,1– 3,* Xue Wu,1– 3 Xiong-Wen Lv1– 3 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University ...
Liu ZN, Su QQ, Wang YH, Wu X, Lv XW
doaj