Results 71 to 80 of about 785,489 (353)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Automatic Classification of Irregularly Sampled Time Series with Unequal Lengths: A Case Study on Estimated Glomerular Filtration Rate

, 2016
A patient's estimated glomerular filtration rate (eGFR) can provide important information about disease progression and kidney function. Traditionally, an eGFR time series is interpreted by a human expert labelling it as stable or unstable.
Bull, Simon, Poh, Norman, Tirunagari, Santosh   +2 more
core   +1 more source

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. [PDF]

, 2009
To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer.
Brennan, C, Broderick, S, Chitale, D, Gerald, W, Golas, B, Gong, Y, Ladanyi, M, Major, J, Motoi, N, Pao, W, Reinersman, J, Rusch, V, Sander, C, Seshan, V, Somwar, R, Szoke, J, Taylor, Barry, Wang, L, Zakowski, M   +18 more
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer.

Journal of Clinical Oncology, 2018
Purpose We report CNS efficacy of osimertinib versus standard epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors (TKIs) in patients with untreated EGFR-mutated advanced non-small-cell lung cancer from the phase III FLAURA study. Patients
T. Reungwetwattana, K. Nakagawa, B. Cho, M. Cobo, E. Cho, A. Bertolini, S. Bohnet, Caicun Zhou, K. Lee, N. Nogami, I. Okamoto, N. Leighl, R. Hodge, A. McKeown, Andrew P. Brown, Y. Rukazenkov, S. Ramalingam, J. Vansteenkiste   +17 more
semanticscholar   +1 more source

The Association of Matrix Metalloproteinases with Chronic Kidney Disease and Peripheral Vascular Disease: A Light at the End of the Tunnel?

Biomolecules, 2020
Chronic Kidney Disease (CKD) represents a risk factor for fatal and nonfatal cardiovascular (CV) events, including peripheral vascular disease (PVD).
Michele Provenzano, Michele Andreucci, Carlo Garofalo, Teresa Faga, Ashour Michael, Nicola Ielapi, Raffaele Grande, Paolo Sapienza, Stefano de Franciscis, Pasquale Mastroroberto, Raffaele Serra   +10 more
doaj   +1 more source

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents.
Mostafa M. Ghorab, Maged S. Abdel-Kader, Ali S. Alqahtani, Aiten M. Soliman   +3 more
doaj   +1 more source

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. [PDF]

, 2007
Members of the epidermal growth factor receptor family (EGFR/ERBB1, ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are key targets for inhibition in cancer therapy.
Bose, Ron, Cole, Philip A, Jura, Natalia, Kuriyan, John, Pickin, Kerry A, Zhang, Xuewu   +5 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Emerging functions of the EGFR in cancer

Molecular Oncology, 2017
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate epithelial tissue development and homeostasis. In pathological settings, mostly in lung and breast cancer and in glioblastoma, the EGFR is a driver of tumorigenesis.
S. Sigismund, D. Avanzato, Letizia Lanzetti   +2 more
semanticscholar   +1 more source