Results 81 to 90 of about 401,950 (315)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

AC099850.3/NCAPG Axis Predicts Poor Prognosis and is Associated with Resistance to EGFR Tyrosine-Kinase Inhibitors in Lung Adenocarcinoma

International Journal of General Medicine, 2022
Jiaqi Bao,1,* Yanlong Wu,2,* Kun Zhang,3 Huijuan Qi4 1Department of Thoracic Surgery, Affiliated Hospital of Chifeng University, Chifeng, People’s Republic of China; 2Department of Urology, Affiliated Hospital of Chifeng University, Chifeng ...
Bao J, Wu Y, Zhang K, Qi H
doaj  

Molecular dynamic simulation, free binding energy calculation of Thiazolo-[2,3-b]quinazolinone derivatives against EGFR-TKD and their anticancer activity

, 2022
Showkat Ahmad Mir, Rajesh Kumar Meher, Iswar Baitharu, Binata Nayak   +3 more
openalex   +1 more source

Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms [PDF]

, 2020
Mark Borris D. Aldonza, Jayoung Ku, Ji‐Young Hong, Donghwa Kim, Seung Jung Yu, Min-Seok Lee, Monica Celine Prayogo, Stephanie Tan, Dayeon Kim, Jinju Han, Sang Kook Lee, Sung Gap Im, Han Suk Ryu, Yoosik Kim   +13 more
openalex   +1 more source

147P PD-L1 expression influenced by osimertinib treatment in advanced EGFR T790M-positive non-small cell lung cancer patients [PDF]

, 2021
Yinghua Yu, Leizhou Xia, Jianying Zhou, K. Wang, Y. Zhang, Chenkai Zhang, A. Liu, Yun Fan, J. Chang, L. Wang, Yihan Li, Shun Lü   +11 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

The EGFR Polymorphism Increased the Risk of Hepatocellular Carcinoma Through the miR-3196-Dependent Approach in Chinese Han Population

Pharmacogenomics and Personalized Medicine, 2021
Li Zhang, Xiaoping Li, Jiang Lu, Yi Qian, Tao Qian, Xing Wu, Qinghua Xu Department of Hepatobiliary and Pancreatic Surgery, LiYang People’s Hospital, LiYang, 213300, Jiangsu, People’s Republic of ChinaCorrespondence: Qinghua Xu; Xing ...
Zhang L, Li X, Lu J, Qian Y, Qian T, Wu X, Xu Q   +6 more
doaj  

Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond Y. H. Yap, Ka Lai Lee, Philip H. Li, Iris Y. K. Tang, Chak Sing Lau, Shirley C. W. Chan   +6 more
wiley   +1 more source

Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation [PDF]

, 2018
Ji Hye Kim, Boas Nam, Yun Jung Choi, Seon Ye Kim, Jungeun Lee, Ki Jung Sung, Woo Sung Kim, Chang‐Min Choi, Eun‐Ju Chang, Jae Soo Koh, Joon Seon Song, Shinkyo Yoon, Jae Cheol Lee, Jin Kyung Rho, Jaekyoung Son   +14 more
openalex   +1 more source