Results 61 to 70 of about 359,207 (273)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

No Evidence of the Ego-Depletion Effect across Task Characteristics and Individual Differences: A Pre-Registered Study. [PDF]

PLoS ONE, 2016
Ego-depletion, a psychological phenomenon in which participants are less able to engage in self-control after prior exertion of self-control, has become widely popular in the scientific community as well as in the media.
John H Lurquin, Laura E Michaelson, Jane E Barker, Daniel E Gustavson, Claudia C von Bastian, Nicholas P Carruth, Akira Miyake   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Stigmatization, Empathy, and the Ego Depletion Hypothesis [PDF]

Pain Medicine, 2011
In their article on “Stigmatization of Patients with Chronic Pain: The Extinction of Empathy,” John Quintner and his colleagues discuss their concerns about physicians' empathic failures [1]. The authors note how unpleasant a physician's encounter can be with patients whose pain is not resolving or becoming manageable. The physician might feel blamable
openaire   +2 more sources

Desempenho em multitarefas, esgotamento do ego e reflexo cognitivo: um estudo em economia comportamental [PDF]

, 2016
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.O presente estudo aborda a influência que o esgotamento de ego causa nas escolhas cognitivas realizadas pelos indivíduos. Para realizar essa análise, foi elaborado
Ludwig, Rafaela
core  

Unsuccessful attempts to replicate effects of self control operations and glucose on ego-depletion pose an interesting research question that demands explanation [PDF]

, 2015
The hypothesis that sugar-containing drinks counteract depletion of self-control or ego resources is elegant and provocative because it entails that the origins of ego-energy and self-control operations can be traced to a physiological substrate. However,
Chatzisarantis, Nikos LD, Hagger, Martin S, Chatzisarantis, Nikos, Hagger, Martin   +3 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source