Results 41 to 50 of about 8,412 (238)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Egocentric networks and physical activity outcomes in Latinas.

PLoS ONE, 2018
ObjectiveDespite data linking the social environment to physical inactivity in Latinas, research on social network predictors of physical activity (PA) is limited.
Becky Marquez, Greg Norman, James Fowler, Kim Gans, Bess Marcus   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Ego-Netzwerke zwischen Paris und Wien

Österreichische Zeitschrift für Geschichtswissenschaften, 2012
The socio-centric approach of social network analysis has become an important analytical paradigm in sociology as well as in historiography whereas ego-centric approaches were either used descriptively or simply ignored.
Veronika Hyden-Hanscho
doaj   +1 more source

Participation in a national diagnostic research study: assessing the patient experience

Orphanet Journal of Rare Diseases, 2023
Introduction The Undiagnosed Diseases Network (UDN), a clinical research study funded by the National Institutes of Health, aims to provide answers for patients with undiagnosed conditions and generate knowledge about underlying disease mechanisms.
Lindsay E. Rosenfeld, Kimberly LeBlanc, Anna Nagy, Braeden K. Ego, The Undiagnosed Diseases Network, Alexa T. McCray   +5 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

HIV disclosure in the social networks of adolescents with HIV in Cape Town, South Africa

Frontiers in Reproductive Health
BackgroundLittle is known about HIV status disclosure within the social networks of adolescents with perinatally-acquired HIV (APHIV) in sub-Saharan Africa, where HIV prevalence is high and stigma surrounding HIV is pervasive.
Marta I. Mulawa, Marta I. Mulawa, Frances Hung, Nicole J. Phillips, Nicole J. Phillips, Mark F. Austin, Richard Barfield, Hui-Jie Lee, Heather J. Zar, Heather J. Zar, Dan J. Stein, Dan J. Stein, Dan J. Stein, Jacqueline Hoare, Jacqueline Hoare   +14 more
doaj   +1 more source

EGO-Centric, Multi-Scale Co-Simulation to Tackle Large Urban Traffic Scenarios

IEEE Access, 2023
Simulating automotive functions that rely on interaction with other vehicles (e.g., perception-based control or algorithms relying on inter-vehicular communication) created a demand for traffic simulation in the automotive field as well.
Balazs Varga, Tamas Ormandi, Tamas Tettamanti   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source