Results 21 to 30 of about 396 (108)

Antibody Responses to Marburg Virus in Egyptian Rousette Bats and Their Role in Protection against Infection [PDF]

Viruses, 2018
Egyptian rousette bats (ERBs) are reservoir hosts for the Marburg virus (MARV). The immune dynamics and responses to MARV infection in ERBs are poorly understood, and limited information exists on the role of antibodies in protection of ERBs against MARV infection.
Nadia Storm, Petrus Jansen Van Vuren, Wanda Markotter, Janusz Paweska   +3 more
exaly   +7 more sources

Unique Features of Immunity within the Immunoglobulin Heavy Chain Locus of Egyptian Rousette Bats [PDF]

The Journal of Immunology, 2020
Abstract The Egyptian fruit bat (Rousettus aegyptiacus, ERB) is reported to be the reservoir of Marburg virus (MARV). Indeed, MARV infection is almost completely asymptomatic in ERBs while eliciting a severe hemorrhagic fever in humans and non-humans primates (NHPs). To understand the biological mechanisms that explain these differential
Maggie L. Bartlett, Peter A. Larson, Mariano Sanchez-Lockhart, Gustavo Palacios   +3 more
doaj   +5 more sources

Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats ( Rousettus aegyptiacus ) [PDF]

Journal of Virology
ABSTRACT Viral coinfections and their impact on long-term immunity represent an understudied area in disease ecology and infectious disease research. Coinfections can influence the host’s susceptibility to future infections, alter host and pathogen population dynamics ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +6 more sources

Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats [PDF]

Nature Communications, 2017
Abstract The Egyptian rousette bat (ERB) is a natural reservoir host for Marburg virus (MARV); however, the mechanisms by which MARV is transmitted bat-to-bat and to other animals are unclear. Here we co-house MARV-inoculated donor ERBs with naive contact ERBs.
Amy J. Schuh, Brian R. Amman, Megan E. B. Jones, Tara K. Sealy, Luke S. Uebelhoer, Jessica R. Spengler, Brock E. Martin, Jo Ann D. Coleman-McCray, Stuart T. Nichol, Jonathan S. Towner   +9 more
doaj   +4 more sources

Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling [PDF]

mBio, 2019
Many RNA viruses that are highly pathogenic in humans are relatively apathogenic in their bat reservoirs, making it important to compare innate immune responses in bats to those well characterized in humans. One such antiviral response is the OAS-RNase L pathway.
Li, Yize, Dong, Beihua, Wei, Zuzhang, Silverman, Robert H., Weiss, Susan R., Patton, John T.   +5 more
doaj   +5 more sources

Human macrophages infected with Egyptian Rousette bat-isolated Marburg virus display inter-individual susceptibility and antiviral responsiveness [PDF]

npj Viruses
AbstractMarburg virus (MARV) is a highly pathogenic filovirus and a causative agent of sporadic zoonotic viral hemorrhagic fever outbreaks with high case fatality rates. In humans, filoviruses like MARV and Zaire Ebola virus (EBOV) target, among others, innate immune cells like dendritic cells and macrophages (MΦs).
Yordanova, Ivet A., Lander, Angelika, Wahlbrink, Annette, Towner, Jonathan S., Albariño, César G., Ang, Lay Teng, Prescott, Joseph B.   +6 more
doaj   +5 more sources

Vector‐borne protozoan and bacterial pathogen occurrence and diversity in ectoparasites of the Egyptian Rousette bat [PDF]

Medical and Veterinary Entomology, 2023
Abstract Bats are known reservoir hosts for a wide variety of parasites and pathogens, including bacteria and protozoans. Some of these pathogens are vector‐borne, and although their role is poorly studied, ectoparasites may contribute significantly to their transmission.
Tamara Szentiványi, Anne‐Caroline Heintz, Wanda Markotter, Jérôme Wassef, Philippe Christe, Olivier Glaizot   +5 more
openaire   +5 more sources

Genomic features of humoral immunity support tolerance model in Egyptian rousette bats [PDF]

Cell Reports, 2021
(Uploaded by Plazi for the Bat Literature Project) Bats asymptomatically harbor many viruses that can cause severe human diseases. The Egyptian rousette bat (ERB) is the only known reservoir for Marburgviruses and Sosuga virus, making it an exceptional animal model to study antiviral mechanisms in an asymptomatic host.
Peter A. Larson, Maggie L. Bartlett, Karla Garcia, Joseph Chitty, Anne Balkema-Buschmann, Jonathan Towner, Jeffrey Kugelman, Gustavo Palacios, Mariano Sanchez-Lockhart   +8 more
openaire   +4 more sources

No evidence for the involvement of the argasid tick Ornithodoros faini in the enzootic maintenance of marburgvirus within Egyptian rousette bats Rousettus aegyptiacus [PDF]

Parasites & Vectors, 2016
(Uploaded by Plazi for the Bat Literature Project) The cave-dwelling Egyptian rousette bat (ERB; Rousettus aegyptiacus) was recently identified as a natural reservoir host of marburgviruses. However, the mechanisms of transmission for the enzootic maintenance of marburgviruses within ERBs are unclear.
Schuh, Amy J., Amman, Brian R., Apanaskevich, Dmitry A., Sealy, Tara K., Nichol, Stuart T., Towner, Jonathan S.   +5 more
exaly   +6 more sources

Tick salivary gland components dampen Kasokero virus infection and shedding in its vertebrate reservoir, the Egyptian rousette bat (Rousettus aegyptiacus) [PDF]

Parasites & Vectors, 2023
Background The human-pathogenic Kasokero virus (KASV) circulates in an enzootic transmission cycle between Egyptian rousette bats (ERBs; Rousettus aegyptiacus) and their argasid tick ectoparasites, Ornithodoros (Reticulinasus) faini.
Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Jonathan S. Towner   +5 more
doaj   +2 more sources