Results 81 to 90 of about 9,885 (133)

Lymphocytosis and Mycobacteriosis in a 15‐Year‐Old Mixed‐Breed Dog

Case Reports in Veterinary Medicine, Volume 2026, Issue 1, 2026.
A 15‐year‐old mixed‐breed dog with T‐cell lymphoid neoplasia with persistent CD8+ lymphocytosis and peripheral lymphadenopathy despite chemotherapy was referred to the Auburn University Veterinary Teaching Hospital Oncology service approximately 7 months after diagnosis.
Bridgette J. Murphy, Ashley A. Smith, Erin M. Kilbane, Francisco O. Conrado, Rita Payan-Carreira   +4 more
wiley   +1 more source

Mitochondrial Dysfunction in Ehrlichia canis Infection

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Transmitted by tick vectors, Ehrlichia canis (E. canis) is a Gram‐negative, obligate intracellular bacterium of zoonotic concern that infects both canine and human hosts. Its pathogenesis centers on the targeting of mononuclear phagocytes, where it establishes an intracellular niche by suppressing phagolysosomal fusion and evading immune detection ...
Xishuai Tong, Jing Jiang, Liu Yang, Yunying Liu, Li Chen, Xiaohui Fu, Gengsheng Yu, Naineng Chen, Shuo Tian, Siyang Huang, Shucheng Huang, Jameel Ahmed Buzdar, Xiang Chen, Zongping Liu, Francesco Mira   +14 more
wiley   +1 more source

Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells.

PLoS Pathogens, 2013
Ehrlichia chaffeensis, an obligatory intracellular rickettsial pathogen, enters and replicates in monocytes/macrophages and several non-phagocytic cells. E.
Dipu Mohan Kumar, Mamoru Yamaguchi, Koshiro Miura, Mingqun Lin, Marek Los, Johannes F Coy, Yasuko Rikihisa   +6 more
doaj   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Transmission electron microscopy reveals distinct macrophage- and tick cell-specific morphological stages of Ehrlichia chaffeensis. [PDF]

PLoS ONE, 2012
Ehrlichia chaffeensis is an emerging tick-borne rickettsial pathogen responsible for human monocytic ehrlichiosis. Despite the induction of an active host immune response, the pathogen has evolved to persist in its vertebrate and tick hosts ...
Sarah E Dedonder, Chuanmin Cheng, Lloyd H Willard, Daniel L Boyle, Roman R Ganta   +4 more
doaj   +1 more source

Ecological dynamics of blacklegged ticks, vertebrate hosts, and associated zoonotic pathogens in northeastern forests

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Specific host‐tick interactions in temperate forest systems influence variation in density and infection prevalence of nymphal blacklegged tick (Ixodes scapularis). The density of infected nymphs (DIN), which is the product of nymphal infection prevalence (NIP) and density of questing nymphs (DON), influences the risk of human exposure to tick‐
Shannon L. LaDeau, Kelly Oggenfuss, Alexander Schmidt, Saravanan Thangamani, Richard S. Ostfeld   +4 more
wiley   +1 more source

Ehrlichia chaffeensis Tandem Repeat Proteins are Related to the RTX Family of Toxins and Secreted by the Type 1 Secretion System

Frontiers in Cellular and Infection Microbiology, 2011
Ehrlichia chaffeensis has type 1 and 4 secretion systems (T1SS and T4SS), but the substrates have not been identified. Potential substrates include secreted tandem repeat protein (TRP) 47, TRP120, and TRP32, and the ankyrin repeat protein, Ank200, that ...
Abdul eWakeel, Amke eden Dulk-Ras, Paul J.J. Hooykaas, Jere W McBride   +3 more
doaj   +1 more source

A Case of Illness Following a Bite by a Male Lone Star Tick (Amblyomma americanum Linnaeus) Infected With Ehrlichia sp. and Rickettsia amblyommatis in Connecticut, United States

Clinical Case Reports, Volume 13, Issue 9, September 2025.
A case of local lymphadenopathy and a flu‐like illness in a man, following a bite by a male lone star tick infected with Ehrlichia sp. and Rickettsia amblyommatis. ABSTRACT The lone star tick (Amblyomma americanum Linnaeus) is a species commonly found in the southeastern U.S., but in recent years its populations have expanded northward, resulting in an
Noelle Khalil, Abigail Chang, Lorelei Sandland, Henry M. Feder Jr., Goudarz Molaei   +4 more
wiley   +1 more source

Ehrlichiosis in a Recent Liver Transplant Recipient Leading to Multiorgan Failure

Case Reports in Transplantation, 2022
Ehrlichia infection has a broad spectrum of diseases ranging from asymptomatic to fatal. While Ehrlichia often presents as a mild form of the disease in immunocompetent patients, immunosuppressed patients are at increased risk for a more virulent and ...
Fawwaz Almajali, Catherine Oleary, Taylor Hallcox, Justin Lok, Daniela Hermelin, Alexis Guenette, Mustafa Nazzal   +6 more
doaj   +1 more source

Descriptive Analysis and Factors Associated With Relapse in Dogs With Presumptive Idiopathic Immune‐Mediated Polyarthritis

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Immune‐mediated polyarthritis (IMPA) is a joint disease common in dogs. Although its prognosis is generally favorable, relapses are frequent, and predictive factors for relapse remain poorly characterized. Objectives To evaluate the outcome of medical management of IMPA in dogs and identify predictive factors for relapse.
Diane Pichard, Thibaud Robin, Kevin Le Boedec, Christelle Maurey, Maxime Kurtz, Fiona Da Riz, Stéphane Blot, Morgane Canonne‐Guibert, Mario Cervone, Emilie Krafft, Jean‐Luc Cadore, Loïc Desquilbet, Ghita Benchekroun   +12 more
wiley   +1 more source