Results 101 to 110 of about 473,950 (309)

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

open access: yesAdvanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen   +11 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

open access: yesAdvanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li   +8 more
wiley   +1 more source

The Impact of Quasi-Conformal Curvature Tensor on Warped Product Manifolds

open access: yesAxioms
This work investigates the effects on the factor manifolds of a singly warped product manifold resulting from the presence of a quasi-conformally flat, quasi-conformally symmetric, or divergence-free quasi-conformal curvature tensor.
Bang-Yen Chen   +4 more
doaj   +1 more source

Construction of an A-manifold on a principal torus bundle

open access: yes, 2012
We construct a new example of an A-manifold, i.e. a Riemannian manifold with a cyclic-parallel Ricci tensor, which can be viewed as a generalization of the Einstein condition.
Zborowski, Grzegorz
core   +1 more source

Einstein structure of four-manifolds

open access: yesJournal of Geometry and Physics
v3: 27 pages, 1 figure, Sections 4 & 5 added; to appear in Journal of Geometry and ...
Jeongwon Ho   +2 more
openaire   +2 more sources

Atomic‐Level Structural Characteristics of β‐Relaxation in Metallic Glasses

open access: yesAdvanced Science, EarlyView.
Using in situ synchrotron radiation X‐ray techniques, this study experimentally characterizes β‐relaxation at the atomic scale, linking it explicitly to tricapped trigonal prism (TTP)‐like atomic structures and fast atomic motions. Cyclic heating reveals β‐relaxation as irreversible yet reactivatable through rejuvenation, offering unprecedented insight
Tianding Xu   +7 more
wiley   +1 more source

On the topology of conformally compact Einstein 4-manifolds

open access: yes, 2003
In this paper we study the topology of conformally compact Einstein 4-manifolds. When the conformal infinity has positive Yamabe invariant and the renormalized volume is also positive we show that the conformally compact Einstein 4-manifold will have at ...
Chang, Alice, Qing, Jie, Yang, Paul
core  

Transport Resistance Dominates the Fill Factor Losses in Record Organic Solar Cells

open access: yesAdvanced Energy Materials, EarlyView.
Organic photovoltaics are a promising solar cell technology, but even the record devices with 20% efficiency have significant fill factor losses due to low active layer conductivities. In this Perspective, the authors describe the origin of these losses, discuss experimental methods for their quantification, and explain how to minimize them to optimize
Chen Wang   +6 more
wiley   +1 more source

A Molecular Descriptor Guided Asymmetric Strategy for High Carrier‐Mobility Light‐Emitting Organic Semiconductors

open access: yesAggregate, EarlyView.
Integrating high photoluminescence quantum yield (PLQY) with high mobility in specific aggregated states remains challenging. Here, we introduce a molecular descriptor, O$O$, to quantitatively predict crystal PLQY. We demonstrate that asymmetric substitution is an effective strategy for achieving high PLQY in high‐mobility H‐aggregated anthracene ...
Jie Liu   +13 more
wiley   +1 more source

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