Results 141 to 150 of about 2,235,192 (340)

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Outcomes of heart failure with preserved ejection fraction (HFpEF) in patients with and without cardiac amyloidosis: analysis from 2016–2019 national inpatient sample [PDF]

, 2022
Soumya Kambalapalli, Nischit Baral, Amith Reddy Seri, S Bhakta   +3 more
openalex   +1 more source

From Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch

Advanced Materials, EarlyView.
A personalizable platform featuring a multi‐zonal cardiac patch design at clinical scale enables precise customization of fiber architecture at micro‐ and macroscale via melt electrowriting. Distinct scaffold zones support cell alignment with mechanical force transfer and epicardial attachment.
Johannes Braig, Ross Kent, Ainitze Gereka Goienetxe, Nicolás Laita, Ming Wu, Miguel Ángel Martínez, Margarida Serra, Koen Janssens, Uzuri Urtaza, Eduardo Larequi, Ilazki Anaut‐Lusar, Hilde Gillijns, Michiel Algoet, Britt van Kerkhof, Maite van der Knaap, Gerardo Cedillo‐Servin, Miguel Castilho, Alain van Mil, Joost P. G. Sluijter, Jos Malda, Piet Claus, Peter H. M. Bovendeerd, Estefanía Peña, Manuel Doblare, Wouter Oosterlinck, Stefan Janssens, Ane M. Zaldua, Olalla Iglesias‐García, Felipe Prósper, Manuel M. Mazo Vega, Jürgen Groll, Tomasz Jüngst   +31 more
wiley   +1 more source

Harnessing Chain Mobility via Protonation for Tough and Isotropic Hydrogel

Advanced Materials, EarlyView.
A protonation‐guided strategy enables ultra‐tough, isotropic PVA hydrogels by temporarily unlocking chain mobility via acidification and fixing homogeneous networks through salting‐out. The resulting materials simultaneously achieve high strength, extreme stretchability, and record‐level toughness, offering a generalizable route toward robust hydrogels
Pengju Shi, Muqing Si, Zishang Lin, Qian Mao, Sidi Duan, Zixiao Liu, Wen Hong, Mason Possinger, Yichen Yan, Chi Chen, Ping He, Xiaobing Zuo, Hua Zhou, Adri van Duin, Ximin He   +14 more
wiley   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Clinical Characteristics of Heart Failure With Preserved Ejection Fraction in Children

, 2013
Masao Nakagawa
openalex   +2 more sources

Rewriting Polymer Fate via Chemomechanical Coupling

Advanced Materials, EarlyView.
This work introduces a life‐like “living” polymer platform that can grow, degrow, and reprogram its properties after fabrication. By integrating mass transport, reversible polymerization, and controlled catalysis, the material achieves on‐demand changes in size, shape, and mechanical properties.
Jiahe Huang, Haohui Zhang, Jiehao Chen, Xuelin Sui, Febby Krisnadi, Dongjing He, Huajian Ji, Will R. Gutekunst, Michael D. Dickey, Yuhang Hu   +9 more
wiley   +1 more source

Impact of Pulmonary Disease on the Prognosis in Heart Failure with Preserved Ejection Fraction: The TOPCAT Trial [PDF]

, 2019
Sérgio Henrique Rodolpho Ramalho, Brian Claggett, Nancy K. Sweitzer, James C. Fang, Sanjiv J. Shah, Inder S. Anand, Bertram Pitt, Eldrin F. Lewis, Marc A. Pfeffer, Scott D. Solomon, Amil M. Shah   +10 more
openalex   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Hydrogelation via Supramolecular Copolymerization of Structural Water within Adaptive Metal–Organic Fibers

Advanced Materials, EarlyView.
Structural water is harnessed as an active co‐monomer to drive supramolecular polymerization in bulk water. Zinc(II) Salphen complexes confine water molecules to form hollow, metal–organic nanofibers that assemble into adaptive hydrogels with thermoresponsive mechanics and selective chiral recognition.
Merlin R. Stühler, Hesam Makki, Tarek Hilal, Debsena Chakraboty, Mathias Dimde, Kai Ludwig, Rainer Haag, Sabine Rosenfeldt, Dorothee Silbernagl, Andreas Schäfer, Alex J. Plajer   +10 more
wiley   +1 more source